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. Author manuscript; available in PMC: 2021 Sep 1.
Published in final edited form as: Circ Arrhythm Electrophysiol. 2020 Jul 27;13(9):e008420. doi: 10.1161/CIRCEP.120.008420

Figure 5.

Figure 5.

Effectiveness of stabilizer cells with GK1 enhanced 4-fold at suppressing (A) DAD-mediated and (B) EAD-mediated TA. Upper panels in (A) and (B): Envelopes for TA probability >10% are superimposed as labeled to show the effects of tissue dimension (1D, 2D, 3D) and the effects of diffusion coefficient (D = 0.0005 cm2/ms, D/10, D/25) and clustering of stabilizer cells (1×1, 3×3, 5×5) in 2D tissue (100×100 cells) as a function of Gspon. Lower panels in (A) and (B): Same for the timing variance of DAD onset (standard deviation of 50 ms, 20 ms and 0, for DADs only), as well as the effects of macroscopic central defects devoid of stabilizer cells (TA probability as a function of the central region diameter) and fibrosis (TA breakthrough probability versus % stabilizer cells and % fibrosis) in 2D tissue (100×100 cells). See Figs. 2 and 3 for further details and comparison to stabilizer cells with Gspon=0.