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. Author manuscript; available in PMC: 2021 Oct 1.
Published in final edited form as: DNA Repair (Amst). 2020 Jun 29;94:102903. doi: 10.1016/j.dnarep.2020.102903

Fig. 3. SRAP active site and mechanism of crosslinking.

Fig. 3.

A,B. Atomic details of the thiazolidine DPC in (A) YedK (PDB ID 6NUA) and (B) HMCES-SRAP (PDB ID 6OE7). DNA is greyscale with AP site dark grey, and SRAP is colored by amino acid. Interatomic distances (Å) are labeled, with hydrogen bonds indicated by dark dashes and close contacts with light dashes. C. Proposed catalytic mechanism of crosslinking.