Table 1.
Compounds identified by interrogating the DSigDB database, using two distinct SARS-CoV-2 – Host interactomes (IA and IB).
| Compound | Hits |
Adjusted p-value |
||
|---|---|---|---|---|
| IA | IB | IA | IB | |
| Acetaminophen | 95 | 5 | 2.03e−4 | 0.044 |
| Amantadine | 7 | 0.019 | ||
| Amikacin | 30 | 1.44e−12 | ||
| Aspirin | 21 | 12 | 0.003 | 0.004 |
| Baclofen | 15 | 1.64e−4 | ||
| Benserazide | 6 | 5 | 0.002 | 0.021 |
| Captopril | 30 | 3 | 2.98e−4 | 0.023 |
| Cimetidine | 40 | 4.60e−7 | ||
| Clindamycin | 95 | 18 | 4.36e−29 | 0.023 |
| Colchicine | 10 | 0.001 | ||
| Copper | 52 | 3.27e−5 | ||
| Dexverapamil | 18 | 1.42e−4 | ||
| Enalapril | 5 | 0.010 | ||
| Fluvastatin | 5 | 0.001 | ||
| Imatinib | 5 | 0.013 | ||
| Lonafarnib | 3 | 0.018 | ||
| Losartan | 4 | 0.045 | ||
| Metoclopramide | 11 | 8.34e−6 | ||
| Metronidazole | 29 | 1.65e-4 | ||
| N-Acetyl-Cysteine | 7 | 0.030 | ||
| Primidone | 5 | 4 | 0.017 | 0.026 |
| Selenium | 57 | 22 | 3.69e−8 | 0.001 |
| Valproic Acid | 175 | 2.16e−7 | ||
| Vitamin E | 53 | 22 | 5.11e−7 | 0.001 |
| Warfarin | 4 | 0.027 | ||
| Zinc | 17 | 0.043 | ||
IΑ refers to the SARS-CoV-2 – host interactome extracted from Bojkova et al’s study; IB refers to the SARS-CoV-2 – host interactome extracted from Guzzi et al’s study. The order of selection was alphabetical, based on first author name. “Hits” refers to the number of genes comprising each drug – associated signature.