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. Author manuscript; available in PMC: 2021 Sep 1.
Published in final edited form as: J Mol Cell Cardiol. 2020 Jul 22;146:95–108. doi: 10.1016/j.yjmcc.2020.07.004

Figure 8. Cardiomyocyte terminal maturation in pigs is delayed compared to mice, despite similar neonatal periods of heart regenerative potential.

Figure 8.

(A) Schematic summary of published postnatal developmental events in murine hearts that coincide with loss of cardiac regenerative capacity at P7. (B) Scheme summarizing our results, where postnatal pig hearts display discordant timing of cardiomyocyte maturational milestones compared to loss of regenerative capacity at P3. Transcriptomic changes in extracellular matrix, immune signaling, sympathetic neuron remodeling, and ROS response are conserved during transition from a regenerative to a non-regenerative postnatal heart in both mice and pigs. *Pig cardiac regenerative window is as described in previous reports [14, 15].