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. Author manuscript; available in PMC: 2021 Oct 1.
Published in final edited form as: Trends Microbiol. 2020 May 4;28(10):821–831. doi: 10.1016/j.tim.2020.04.004

Figure 4: Model for manganese ion homeostasis in S. aureus.

Figure 4:

Mn2+ ions are imported into the cell by the MntABC and MntH transporters. The MntR transcriptional regulator binds intracellular manganese and represses transcription of mntABC. It is unclear if transcription of mntH is Mn-dependent and/or regulated by MntR. To prevent cytotoxicity, excess Mn is effluxed by MntE. While upregulation of mntE is dependent on the presence of MntR, it is not known if this effect is a result of direct or indirect regulation.