Table 4.
Scores on the Modified Mini-Mental State Exam (mMMS) and the Columbia University Autobiographical Memory Interview (CUAMI) for the Mode 1 Only and Mode 2 Samples Across Assessment Time Points in the Columbia University Studies
| Mode 2 Sample |
||||||||
|---|---|---|---|---|---|---|---|---|
| Mode 1 Only | Mode 2 Sample | P-Value* | Weak ECT | Strong ECT | High Dose BL ECT | P-Value* | ||
| mMMS | ||||||||
| Pre-ECT | Mean | 49.72 | 49.58 | 0.86 | 48.83 | 50.21 | 51.55 | 0.42 |
| SD | 5.98 | 6.89 | 7.18 | 6.45 | 6.55 | |||
| N | 159 | 92 | 53 | 28 | 11 | |||
| Post Mode 1 | Mean | 47.5 | 48.87 | 0.07 | 49.10 | 48.70 | 48.27 | 0.13 |
| SD | 7.57 | 6.76 | 7.58 | 5.01 | 7.21 | |||
| N | 149 | 86 | 48 | 27 | 11 | |||
| Post Mode 2 | Mean | 45.37 | 44.00 | 47.56 | 46.50 | 0.43 | ||
| SD | 6.99 | 7.42 | 5.83 | 6.49 | ||||
| N | 83 | 48 | 25 | 10 | ||||
| Two-Month Follow-up | Mean | 51.05 | 50.6 | 0.29 | 50.14 | 50.88 | 52.00 | 0.82 |
| SD | 5.42 | 5.45 | 5.53 | 5.84 | 4.54 | |||
| N | 104 | 60 | 35 | 17 | 8 | |||
| Six-Month Follow-up† | Mean | 52.26 | 51.33 | 0.02 | 48.30 | 54.43 | 53.50 | 0.12 |
| SD | 4.76 | 4.95 | 5.52 | 1.72 | 2.65 | |||
| N | 43 | 21 | 10 | 7 | 4 | |||
| CUAMI Consistency Score | ||||||||
| Post Mode 1 | Mean | 66.6 | 69.91 | 0.21 | 72.78 | 67.24 | 60.77 | 0.03 |
| SD | 14.14 | 12.07 | 10.43 | 12.18 | 15.66 | |||
| N | 135 | 76 | 46 | 22 | 8 | |||
| Post Mode 2‡ | Mean | 50.09 | 41.95 | 55.30 | 51.38 | 0.34 | ||
| SD | 19.41 | 16.10 | 18.60 | 37.92 | ||||
| N | 22 | 8 | 12 | 2 | ||||
| Two-Month Follow-up | Mean | 71.51 | 61.52 | 0.0002 | 62.87 | 58.17 | 63.35 | 0.67 |
| SD | 11.24 | 19.02 | 17.34 | 24.32 | 11.04 | |||
| N | 87 | 57 | 34 | 17 | 6 | |||
| Six-Month Follow-up‡ | Mean | 72.03 | 59.62 | 0.01 | 50.24 | 70.75 | 52.63 | 0.07 |
| SD | 11.55 | 13.71 | 9.12 | 10.92 | -- | |||
| N | 26 | 9 | 4 | 4 | 1 | |||
P-values reflect independent t-tests comparing the Mode 1 and Mode 2 groups or one-way analyses of variance (ANOVAs) comparing the three Mode 1 ECT classifications.
mMMS assessment at six-month follow-up was not conducted in Study 2.
CUAMI data were available only for Study 4 at the post Mode 2 and six-month follow-up assessments.