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. Author manuscript; available in PMC: 2021 Oct 1.
Published in final edited form as: Dev Biol. 2020 Aug 7;466(1-2):47–58. doi: 10.1016/j.ydbio.2020.08.003

Figure 9: Schematic illustration of the proposed mechanism of Piezo1 – Yap regulation of epithelial and mesenchymal remodeling.

Figure 9:

(1) Drainage and re-accumulation of amniotic fluid in the laryngeal region cause delayed and rapid EL recanalization which altered VF shape and led to VF tissue deformation. (2) Overall VF tissue deformation then activated Piezo 1 sensory channels in the plasma membrane of VF epithelial cells, which triggered Yap translocation into the nucleus (3) and promoted expression of target genes (4) involved in epithelial stratification (5) and extracellular matrix remodeling in the lamina propria (6). Abbreviation: ECM, extracellular matrix; EL, epithelial lamina; VF, vocal folds.