Table 10.
Thirteen-weeks repeated dose toxicity and four-weeks recovery study: absolute organ weights of male rats (main study) and absolute organ weights of female rats (main study)
| Summary of absolute organ weights | ||||
|---|---|---|---|---|
| Organs | Group (mg/kg/day) sex: male | |||
| G1 (0) | G2 (500) | G3 (1000) | G4 (2000) | |
| Body weighta | 535.73 ± 84.83 (10) | 535.22 ± 62.92 (10) | 490.29 ± 63.21 (10) | 489.69 ± 49.94 (10) |
| Testis (Lt) | 1.7813 ± 0.1841 (10) | 1.7714 ± 0.2152 (10) | 1.7468 ± 0.2339 (10) | 1.8673 ± 0.1526 (10) |
| Testis (Rt) | 1.7802 ± 0.2017 (10) | 1.7890 ± 0.2088 (10) | 1.7431 ± 0.2133 (10) | 1.8763 ± 0.1677 (10) |
| Prostate | 0.7915 ± 0.1978 (10) | 0.9267 ± 0.1106 (10) | 0.8057 ± 0.2603 (10) | 0.7445 ± 0.1951 (10) |
| Spleen | 0.8705 ± 0.1257 (10) | 0.8918 ± 0.1397 (10) | 0.8390 ± 0.1635 (10) | 0.8091 ± 0.1094 (10) |
| Liver | 16.0900 ± 2.7647(10) | 17.0546 ± 3.3324(10) | 15.3102 ± 2.3546(10) | 16.0392 ± 1.9907(10) |
| Adrenal gland (Lt) | 0.0288 ± 0.0042 (10) | 0.0300 ± 0.0074 (10) | 0.0256 ± 0.0035 (10) | 0.0268 ± 0.0049 (10) |
| Adrenal gland (Rt.) | 0.0284 ± 0.0043 (10) | 0.0300 ± 0.0051 (10) | 0.0260 ± 0.0042 (10) | 0.0260 ± 0.0036 (10) |
| Kidney (Lt.) | 1.6634 ± 0.1897 (10) | 1.6672 ± 0.1708 (10) | 1.5449 ± 0.1997 (10) | 1.5439 ± 0.1833 (10) |
| Kidney (Rt.) | 1.7031 ± 0.1927 (10) | 1.7161 ± 0.1781 (10) | 1.5681 ± 0.1632 (10) | 1.5819 ± 0.2258 (10) |
| Heart | 1.6654 ± 0.2586 (10) | 1.7142 ± 0.2137 (10) | 1.4698 ± 0.1986 (10) | 1.5341 ± 0.1801 (10) |
| Lung | 1.7255 ± 0.2003 (10) | 1.7596 ± 0.1421 (10) | 1.7341 ± 0.2641 (10) | 1.7563 ± 0.1444 (10) |
| Brain | 2.1120 ± 0.1244 (10) | 2.1616 ± 0.1015 (10) | 2.1626 ± 0.1531 (10) | 2.1508 ± 0.0684 (10) |
| Pituitary | 0.0115 ± 0.0024 (10) | 0.0138 ± 0.0025 (10) | 0.0117 ± 0.0026 (10) | 0.0124 ± 0.0016 (10) |
| Thymus | 0.3541 ± 0.0959 (10) | 0.3052 ± 0.1068 (10) | 0.3259 ± 0.1225 (10) | 0.2721 ± 0.0641 (10) |
| Summary of absolute organ weights | ||||
|---|---|---|---|---|
| Organs | Group (mg/kg/day) sex: female | |||
| G1 (0) | G2 (500) | G3 (1000) | G4 (2000) | |
| Body weighta | 318.86 ± 26.31 (10) | 319.01 ± 28.27 (10) | 333.19 ± 25.50 (10) | 302.30 ± 30.84 (10) |
| Testis (Lt) | 0.0484 ± 0.0125 (10) | 0.0488 ± 0.0103 (10) | 0.0538 ± 0.0108 (10) | 0.0424 ± 0.0104 (10) |
| Testis (Rt) | 0.0421 ± 0.0132 (10) | 0.0483 ± 0.0114 (10) | 0.0553 ± 0.0076*(10) | 0.0437 ± 0.0097 (10) |
| Prostate | 0.6989 ± 0.2967 (10) | 0.7401 ± 0.2401 (10) | 0.7946 ± 0.3375 (10) | 0.6031 ± 0.3655 (10) |
| Spleen | 0.5631 ± 0.0859 (10) | 0.5741 ± 0.0538 (10) | 0.6382 ± 0.1002 (10) | 0.5517 ± 0.1132 (10) |
| Liver | 7.8426 ± 0.8494 (10) | 8.0393 ± 0.8365 (10) | 8.0891 ± 0.5265 (10) | 7.9703 ± 0.8543 (10) |
| Adrenal gland (Lt) | 0.0385 ± 0.0053 (10) | 0.0358 ± 0.0068 (10) | 0.0387 ± 0.0062 (10) | 0.0340 ± 0.0073 (10) |
| Adrenal gland (Rt.) | 0.0391 ± 0.0057 (10) | 0.0347 ± 0.0059 (10) | 0.0366 ± 0.0081 (10) | 0.0351 ± 0.0061 (10) |
| Kidney (Lt.) | 1.0138 ± 0.1077 (10) | 1.0473 ± 0.0658 (10) | 1.0376 ± 0.0840 (10) | 1.0042 ± 0.0722 (10) |
| Kidney (Rt.) | 1.0285 ± 0.1296 (10) | 1.0688 ± 0.0952 (10) | 1.0497 ± 0.0866 (10) | 1.0336 ± 0.0936 (10) |
| Heart | 1.0887 ± 0.0804 (10) | 1.0921 ± 0.1448 (10) | 1.2278 ± 0.2875 (10) | 1.0952 ± 0.0668 (10) |
| Lung | 1.3680 ± 0.1085 (10) | 1.3501 ± 0.0796 (10) | 1.4233 ± 0.1236 (10) | 1.4048 ± 0.1979 (10) |
| Brain | 1.9743 ± 0.0425 (10) | 1.9943 ± 0.1132 (10) | 2.0501 ± 0.1255 (10) | 1.9846 ± 0.0912 (10) |
| Pituitary | 0.0206 ± 0.0034 (10) | 0.0184 ± 0.0046 (10) | 0.0167 ± 0.0048 (10) | 0.0180 ± 0.0042 (10) |
| Thymus | 0.2648 ± 0.0499 (10) | 0.2939 ± 0.0636 (10) | 0.2872 ± 0.0687 (10) | 0.2813 ± 0.0537 (10) |
Mean ± SD (Number of animals)
Lt. left, Rt. right
aAt necropsy
Significant difference compared with the control group value: *p < 0.05