Table 11.
Four-weeks repeated dose toxicity: Hematological values of male dogs and Hematological values of female dogs
| Individual data of hematological test | ||||||||
|---|---|---|---|---|---|---|---|---|
| Animal ID | Group (mg/kg/day) sex: male | |||||||
| G1 (0) | G2 (250) | G3 (500) | G4 (1000) | |||||
| 256-1 | 256-2 | 256-3 | 256-4 | |||||
| Test item | Before | After | Before | After | Before | After | Before | After |
| WBC1 (K/μL) | 7.83 | 6.33 | 10.09 | 7.91 | 9.57 | 7.04 | 13.69 | 13.12 |
| RBC2 (M/μL) | 6.81 | 7.48 | 6.3 | 7.5 | 6.38 | 7.57 | 6.24 | 6.5 |
| HGB3 (g/dL) | 15.6 | 17.6 | 13.9 | 16.4 | 13.4 | 16.2 | 14.5 | 14.6 |
| HCT4 (%) | 48.4 | 52 | 42.4 | 49.4 | 41.8 | 49 | 42.5 | 44.4 |
| MCV5 (fL) | 71.2 | 69.6 | 67.4 | 65.9 | 65.5 | 64.8 | 68 | 68.2 |
| MCH6 (pg) | 22.9 | 23.5 | 22.1 | 21.9 | 21 | 21.4 | 23.2 | 22.4 |
| MCHC7 (g/dL) | 32.1 | 33.8 | 32.8 | 33.2 | 32.1 | 33.1 | 34.1 | 32.9 |
| RDW8 (%) | 12.6 | 12.9 | 12.9 | 13.3 | 13.6 | 13.5 | 12.8 | 12.8 |
| PLT9 (K/μL) | 214 | 189 | 368 | 292 | 298 | 219 | 296 | 346 |
| MPV10 (fL) | 11.5 | 11.9 | 7.9 | 8.8 | 9.4 | 9.6 | 9.3 | 9.6 |
| NEP11 (%) | 43.8 | 49.7 | 48 | 43.7 | 47.1 | 48.2 | 54.9 | 54 |
| LYP12 (%) | 42.4 | 40.4 | 37 | 45.4 | 37 | 39.2 | 34.2 | 36.5 |
| MOP13 (%) | 7.1 | 5.2 | 7.5 | 6 | 8.7 | 7.1 | 7.6 | 6.4 |
| EOP14 (%) | 5.8 | 3.5 | 6.1 | 2.9 | 6.4 | 4 | 2.8 | 1.8 |
| LUP15 (%) | 0.5 | 0.2 | 0.7 | 0.8 | 0.5 | 0.2 | 0.3 | 0.3 |
| BAP16 (%) | 0.4 | 1 | 0.7 | 1.2 | 0.3 | 1.2 | 0.1 | 1 |
| LYM17 (K/μL) | 3.32 | 2.55 | 3.73 | 3.59 | 3.54 | 2.76 | 4.68 | 4.79 |
| MO18 (K/μL) | 0.56 | 0.33 | 0.76 | 0.48 | 0.83 | 0.5 | 1.04 | 0.84 |
| EO19 (K/μL) | 0.46 | 0.22 | 0.62 | 0.23 | 0.62 | 0.28 | 0.39 | 0.24 |
| LUC20 (K/μL) | 0.04 | 0.01 | 0.07 | 0.07 | 0.05 | 0.02 | 0.04 | 0.04 |
| Retic21 (K/μL) | 2.02 | 1.72 | 1.45 | 1.46 | 1.48 | 1.24 | 1.9 | 1.93 |
| Individual data of hematological test | ||||||||
|---|---|---|---|---|---|---|---|---|
| Animal ID | Group (mg/kg/day) sex: female | |||||||
| G1 (0) | G2 (250) | G3 (500) | G4 (1000) | |||||
| 256-5 | 256-6 | 256-7 | 256-8 | |||||
| Test item | Before | After | Before | After | Before | After | Before | After |
| WBC1 (K/μL) | 13.93 | 9.58 | 11.79 | 11.21 | 7.93 | 9.23 | 10.24 | 7.94 |
| RBC2 (M/μL) | 7.12 | 7.64 | 8 | 7.92 | 7.31 | 8.04 | 7.51 | 7.79 |
| HGB3 (g/dL) | 16 | 17.4 | 17.8 | 18.3 | 16.6 | 18.3 | 15.2 | 16.2 |
| HCT4 (%) | 49.6 | 52.6 | 53.5 | 53.1 | 50.9 | 54.2 | 48 | 48.6 |
| MCV5 (fL) | 69.7 | 68.9 | 66.9 | 67 | 69.6 | 67.4 | 64 | 62.4 |
| MCH6 (pg) | 22.5 | 22.8 | 22.3 | 23.1 | 22.7 | 22.8 | 20.2 | 20.8 |
| MCHC7 (g/dL) | 32.3 | 33.2 | 33.3 | 34.5 | 32.5 | 33.8 | 31.7 | 33.4 |
| RDW8 (%) | 13.2 | 13 | 13.9 | 12.6 | 11.8 | 11.5 | 15.2 | 14.2 |
| PLT9 (K/μL) | 405 | 310 | 284 | 267 | 258 | 281 | 358 | 293 |
| MPV10 (fL) | 7.8 | 8.5 | 8.6 | 9.3 | 8.9 | 9.4 | 8.9 | 8.6 |
| NEP11 (%) | 41.5 | 46.5 | 38.3 | 41.6 | 54.7 | 55.8 | 51.6 | 51.9 |
| LYP12 (%) | 44.6 | 46.5 | 53.8 | 51.2 | 35.8 | 35.1 | 38.7 | 41.3 |
| MOP13 (%) | 7.1 | 4.8 | 4.5 | 4.6 | 6.9 | 5.7 | 5.3 | 4.3 |
| EOP14 (%) | 6.1 | 1.4 | 2.5 | 1.7 | 1.8 | 2 | 3.4 | 1.8 |
| LUP15 (%) | 0.5 | 0.4 | 0.4 | 0.4 | 0.4 | 0.2 | 0.7 | 0.3 |
| BAP16 (%) | 0.3 | 0.4 | 0.4 | 0.4 | 0.3 | 1.1 | 0.3 | 0.4 |
| NE17 (K/μL) | 5.77 | 4.46 | 4.52 | 4.67 | 4.34 | 5.15 | 5.28 | 4.12 |
| LYM18 (K/μL) | 6.21 | 4.45 | 6.34 | 5.74 | 2.84 | 3.24 | 3.97 | 3.28 |
| MO19 (K/μL) | 0.99 | 0.46 | 0.53 | 0.52 | 0.55 | 0.53 | 0.54 | 0.34 |
| EO20 (K/μL) | 0.85 | 0.13 | 0.29 | 0.19 | 0.14 | 0.18 | 0.35 | 0.14 |
| LUC21 (K/μL) | 0.06 | 0.04 | 0.05 | 0.05 | 0.03 | 0.02 | 0.07 | 0.02 |
| BA22 (K/μL) | 0.04 | 0.04 | 0.05 | 0.05 | 0.02 | 0.1 | 0.03 | 0.03 |
| Retic23 (K/μL) | 2.85 | 2.13 | 2.44 | 1.94 | 2.13 | 0.97 | 2.51 | 1.57 |
1: white blood cell, 2: red blood cell, 3: hemoglobin, 4: hematocrit 5: mean corpuscular volume, 6: mean corpuscular hemoglobin, 7: mean corpuscular hemoglobin concentration, 8: red cell distribution width, 9: platelet, 10: mean platelet volume, 11: percent of neutrophils, 12: percent of lymphocyte 13: percent of monocyte; 14: percent of eosinophil, 15: percent of large unstained cell, 16: percent of basophil, 17 neutrophils, 18: lymphocyte, 19: monocyte, 20: eosinophil, 21: large unstained cell, 22: basophil, 23: reticulocyte