Table 2.
The number of cells with chromosome aberrations per 100 metaphase cells
| Exposurea | S9 mix | Dose (μg/mL) | Number of total chromosome aberrations (mean) | Number of cells with chromosome aberrations (mean) | PP + ER (mean) | ||
|---|---|---|---|---|---|---|---|
| (−)Gap | (+)Gap | (−)Gap | (+)Gap | ||||
| 24–0 | – | Negative control | 0.33 | 0.33 | 0.33 | 0.33 | 0.00 |
| – | 2.29 | 0.67 | 0.67 | 0.67 | 0.67 | 0.00 | |
| – | 6.86 | 0.67 | 0.67 | 0.67 | 0.67 | 0.00 | |
| – | 20.58 | 1.33 | 1.33 | 1.33 | 1.33 | 0.00 | |
| – | MMC (0.04) | 25.67 | 26.00 | 25.67* | 26.00 | 0.00 | |
| 6–18 | – | Negative control | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
| 6.86 | 0.33 | 0.33 | 0.33 | 0.33 | 0.00 | ||
| 50.28 | 0.67 | 1.00 | 0.67 | 1.00 | 0.00 | ||
| 61.73 | 0.67 | 0.67 | 0.67 | 0.67 | 0.00 | ||
| MMC (0.04) | 23.00 | 23.00 | 23.00* | 23.00 | 0.00 | ||
| Negative control | 0.67 | 0.67 | 0.67 | 0.67 | 0.00 | ||
| 6.86 | 0.67 | 0.67 | 0.67 | 0.67 | 0.00 | ||
| 20.58 | 0.67 | 0.67 | 0.67 | 1.00 | 0.00 | ||
| 61.73 | 1.00 | 1.00 | 1.00 | 1.00 | 0.00 | ||
| B[a]P (20) | 23.33 | 23.67 | 23.33* | 23.67 | 0.00 | ||
Mean ± SD (number of animals). Significantly different from the negative control at p < 0.05
MMC mitomycin C (0.04 μg/mL), B[a]P benzo[a]pyrene (20 μg/mL), PP polyploidy, ER endoreduplication
aTreatment time-recovery time