Table 3.

Micronuclei frequency and cytotoxicity

Groups		Dose (mg/kg)	Animal No.	MNPCE/4000 PCEs (mean ± SD, %)		PCE/(PCE + NCE) (mean ± SD, BW/day)
Negative control	Vehicle	0	1	0.25	(0.25 ± 0.07)	0.53	(0.50 ± 0.03)
			2	0.28		0.47
			3	0.30		0.50
			4	0.30		0.53
			5	0.13		0.49
Test substance	APRG64	500	6	0.28	(0.29 ± 0.11)	0.43	(0.51 ± 0.05)
			7	0.18		0.53
			8	0.43		0.52
			9	0.38		0.50
			10	0.18		0.58
		1000	11	0.08	(0.32 ± 0.20)	0.54	(0.52 ± 0.02)
			12	0.43		0.51
			13	0.15		0.49
			14	0.43		0.53
			15	0.53		0.53
		2000	16	0.35	(0.34 ± 0.05)	0.48	(0.53 ± 0.05)
			17	0.38		0.49
			18	0.25		0.50
			19	0.35		0.59
			20	0.38		0.58
Positive control	MMC	2.0	21	8.35	(10.43 ± 1.56)**	0.49	(0.48 ± 0.01)
			22	12.68		0.48
			23	9.85		0.49
			24	10.63		0.46
			25	10.65		0.47

Vehicle distilled water

Mean ± SD (number of animals)

MNPCE micronucleated polychromatic erythrocytes, PCE Polychromatic erythrocyte, NCE normochromatic erythrocyte, MMC mitomycin C

Significantly different from the control at **p < 0.01