Table 8.
Summary of hematological tests (sex: male) | ||||
---|---|---|---|---|
Test item | Main group (mg/kg/day) | |||
G1 (0) | G2 (500) | G3 (1000) | G4 (2000) | |
WBC1 (K/μL) | 6.66 ± 1.46 (10) | 8.57 ± 1.57 (10) | 8.53 ± 3.35 (10) | 9.33 ± 2.89 (10) |
NE2 (K/μL) | 0.96 ± 0.28 (10) | 1.25 ± 0.55 (10) | 1.22 ± 0.48 (10) | 1.33 ± 0.53 (10) |
EO3 (K/μL) | 0.06 ± 0.03 (10) | 0.10 ± 0.07 (10) | 0.09 ± 0.04 (10) | 0.08 ± 0.04 (10) |
BA4 (K/μL) | 0.01 ± 0.01 (10) | 0.00 ± 0.01 (10) | 0.01 ± 0.01 (10) | 0.01 ± 0.01 (10) |
LY5 (K/μL) | 5.37 ± 1.29 (10) | 6.95 ± 1.47 (10) | 6.91 ± 2.93 (10) | 7.62 ± 2.30 (10) |
MO6 (K/μL) | 0.14 ± 0.07 (10) | 0.18 ± 0.06 (10) | 0.17 ± 0.08 (10) | 0.17 ± 0.08 (10) |
LUC7 (K/μL) | 0.12 ± 0.08 (10) | 0.10 ± 0.03 (10) | 0.12 ± 0.08 (10) | 0.13 ± 0.07 (10) |
NEP8 (%) | 14.8 ± 3.9 (10) | 14.8 ± 6.1 (10) | 15.0 ± 5.2 (10) | 14.0 ± 3.0 (10) |
EOP9 (%) | 1.0 ± 0.5 (10) | 1.2 ± 0.8 (10) | 1.1 ± 0.4 (10) | 0.8 ± 0.3 (10) |
BAP10 (%) | 0.1 ± 0.1 (10) | 0.1 ± 0.1 (10) | 0.1 ± 0.1 (10) | 0.0 ± 0.0 (10) |
LYP11 (%) | 80.4 ± 5.0 (10) | 80.8 ± 7.2 (10) | 80.5 ± 5 2 (10) | 82.1 ± 3.7 (10) |
MOP12 (%) | 2.1 ± 0.9 (10) | 2.1 ± 0.7 (10) | 1.9 ± 0.6 (10) | 1.7 ± 0.5 (10) |
LUP13 (%) | 1.8 ± 0.9 (10) | 1.1 ± 0.2 (10) | 1.4 ± 0.4 (10) | 1.3 ± 0.4 (10) |
RBC14 (M/μL) | 7.94 ± 0.28 (10) | 7.92 ± 0.35 (10) | 7.68 ± 0.55 (10) | 7.93 ± 0.34 (10) |
Hb15 (g/dL) | 14.3 ± 0.6 (10) | 14.6 ± 0.9 (10) | 14.4 ± 0.4 (10) | 14.4 ± 0.5 (10) |
RDW16 (%) | 12.8 ± 1.0 (10) | 12.7 ± 0.8 (10) | 12.7 ± 0.8 (10) | 12.5 ± 0.9 (10) |
HCT17 (%) | 44.3 ± 1.9 (10) | 44.8 ± 2.7 (10) | 43.8 ± 2.4 (10) | 44.7 ± 1.4 (10) |
MCV18 (fL) | 55.8 ± 1.5 (10) | 56.5 ± 2.1 (10) | 57.1 ± 2.7 (10) | 56.4 ± 1.4 (10) |
MCH19 (pg) | 18.0 ± 0.5 (10) | 18.4 ± 0.8 (10) | 18.8 ± 1.2 (10) | 18.2 ± 0.4 (10) |
MCHC20 (g/dL) | 32.4 ± 0.5 (10) | 32.6 ± 1.0 (10) | 32.9 ± 1.4 (10) | 32.3 ± 0.5 (10) |
Retic21 (%) | 2.21 ± 0.45 (10) | 2.36 ± 0.37 (10) | 2.42 ± 0.74 (10) | 2.13 ± 0.53 (10) |
PLT22 (K/μL) | 901 ± 86 (10) | 892 ± 150 (10) | 927 ± 121 (10) | 957 ± 150 (10) |
MPV23 (fL) | 5.0 ± 0.2 (10) | 4.9 ± 0.2 (10) | 5.0 ± 0.3 (10) | 5.1 ± 0.2 (10) |
Summary of hematological tests (sex: female) | ||||
---|---|---|---|---|
Test item | Group (mg/kg/day) | |||
G1 (0) | G2 (500) | G3 (1000) | G4 (2000) | |
WBC1 (K/μL) | 3.99 ± 0.49 (10) | 4.32 ± 1.15 (10) | 5.04 ± 1.33 (10) | 5.36 ± 1.06* (10) |
NE2 (K/μL) | 0.74 ± 0.15 (10) | 0.87 ± 0.60 (10) | 0.67 ± 0.21 (10) | 0.95 ± 0.34 (10) |
EO3 (K/μL) | 0.06 ± 0.01 (10) | 0.06 ± 0.03 (10) | 0.07 ± 0.03 (10) | 0.08 ± 0.02 (10) |
BA4 (K/μL) | 0.01 ± 0.01 (10) | 0.01 ± 0.01 (10) | 0.01 ± 0.01 (10) | 0.00 ± 0.01 (10) |
LY5 (K/μL) | 3.08 ± 0.57 (10) | 3.24 ± 0.85 (10) | 4.13 ± 1.23* (10) | 4.17 ± 0.82* (10) |
MO6 (K/μL) | 0.10 ± 0.04 (10) | 0.12 ± 0.05 (10) | 0.14 ± 0.06 (10) | 0.14 ± 0.07 (10) |
LUC7 (K/μL) | 0.02 ± 0.01 (10) | 0.02 ± 0.01 (10) | 0.02 ± 0.02 (10) | 0.02 ± 0.01 (10) |
NEP8 (%) | 18.9 ± 4.8 (10) | 19.6 ± 8.8 (10) | 13.8 ± 4.9 (10) | 17.6 ± 4.8 (10) |
EOP9 (%) | 1.4 ± 0.3 (10) | 1.5 ± 0.4 (10) | 1.5 ± 0.5 (10) | 1.4 ± 0.4 (10) |
BAP10 (%) | 0.1 ± 0.1 (10) | 0.2 ± 0.1 (10) | 0.2 ± 0.2 (10) | 0.1 ± 0.1 (10) |
LYP11 (%) | 76.7 ± 5.5 (10) | 75.7 ± 9.0 (10) | 81.4 ± 5.7 (10) | 78.0 ± 5.3 (10) |
MOP12 (%) | 2.4 ± 0.9 (10) | 2.6 ± 0.7 (10) | 2.7 ± 1.2 (10) | 2.6 ± 1.2 (10) |
LUP13 (%) | 0.4 ± 0.1 (10) | 0.5 ± 0.3 (10) | 0.4 ± 0.2 (10) | 0.3 ± 0.2 (10) |
RBC14 (M/μL) | 7.70 ± 0.24 (10) | 7.58 ± 0.31 (10) | 7.61 ± 0.27 (10) | 7.41 ± 0.42 (10) |
Hb15 (g/dL) | 14.5 ± 0.4 (10) | 14.6 ± 0.5 (10) | 14.6 ± 0.3 (10) | 14.4 ± 0.7 (10) |
RDW16 (%) | 11.0 ± 0.2 (10) | 11.1 ± 0.3 (10) | 10.9 ± 0.3 (10) | 10.9 ± 0.5 (10) |
HCT17 (%) | 43.6 ± 1.5 (10) | 43.2 ± 1.4 (10) | 43.3 ± 1.3 (10) | 43.0 ± 2.1 (10) |
MCV18 (fL) | 56.6 ± 1.0 (10) | 57.0 ± 1.0 (10) | 56.8 ± 1.3 (10) | 58.1 ± 1.3* (10) |
MCH19 (pg) | 18.9 ± 0.6 (10) | 19.3 ± 0.5 (10) | 19.2 ± 0.5 (10) | 19.4 ± 0.5 (10) |
MCHC20 (g/dL) | 33.6 ± 0.6 (10) | 33.9 ± 0.6 (10) | 33.7 ± 0.7 (10) | 33.5 ± 0.6 (10) |
Retic21 (%) | 1.78 ± 0.35 (10) | 1.95 ± 0.30 (10) | 1.89 ± 0.42 (10) | 1.98 ± 0.50 (10) |
PLT22 (K/μL) | 1048 ± 131 (10) | 1007 ± 72 (10) | 1076 ± 130 (10) | 1034 ± 74 (10) |
MPV23 (fL) | 5.1 ± 0.2 (10) | 5.0 ± 0.2 (10) | 5.1 ± 0.3 (10) | 4.9 ± 0.2 (10) |
1: white blood cell, 2: neutrophil, 3: eosinophil, 4: basophil, 5: lymphocyte, 6: monocyte, 7: large unstained cell, 8: percent of neutrophil, 9: percent of eosinophil, 10: percent of basophil, 11: percent of lymphocyte, 12: percent of monocyte, 13: percent of large unstained cell, 14: red blood cell, 15: hemoglobin, 16: red cell distribution width, 17: hematocrit, 18: mean corpuscular volume, 19: mean corpuscular hemoglobin, 20: mean corpuscular hemoglobin concentration, 21: reticulocyte, 22: platelet, 23: mean platelet volume
Mean ± SD (Number of animals)
Significant difference compared with the control group value: *p < 0.05