Table 1.
Effect of α-lipoic acid (LA) on reproductive performance and androgen-dependent developmental landmarks in F1 pups of controls and linuron-treated rats
| Parameters | Controls | Linuron | Linuron + LA | ||
|---|---|---|---|---|---|
| 10 mg/Kg | 50 mg/Kg | 10 mg/Kg | 50 mg/Kg | ||
| Number of female rats | 10 | 10 | 10 | 10 | 10 |
| Number of male rats | 10 | 10 | 10 | 10 | 10 |
| Conception time (days) | 1.2a ± 0.68 | 3.8b ± 0.42 | 4.91c ± 0.31 | 2.3d ± 0.21 | 2.5e ± 0.31 |
| Mating index (%) | 100 (10/10) | 70 (7/10) | 60 (6/10) | 80 (8/10) | 80 (8/10) |
| Fertility index (%) | 100 (10/10) | 100 (7/7) | 100 (6/6) | 100 (8/8) | 90 (7/8) |
| No. of. live pups/rat | 11.7a ± 1.2 | 5.2b ± 0.22 | 4.7b ± 0.35 | 7.2c ± 0.38 | 6.9c ± 0.36 |
| Body weights of pups# (Postnatal day: PND 1) | 5.04a ± 0.28 | 4.97a ± 0.34 | 4.9a ± 0.40 | 5.1a ± 0.21 | 5.07a ± 0.33 |
| Anogenital distance# (cm) on PND 1 | 0.37a ± 0.028 | 0.36a ± 0.038 | 0.37a ± 0.041 | 0.35a ± 0.057 | 0.36a ± 0.052 |
| Testicular descent# (PND) | 24.9a ± 1.10 | 32.1b ± 0.99 | 33.9c ± 1.72 | 26.6d ± 0.69 | 30.3e ± 1.41 |
Data are expressed as mean ± SD
a–eDifferent superscripts in the same row indicate a significant difference (p < 0.05)
#n = 10