Table 3.
Adjusted regression coefficients a for birth weight associated with maternal thyroid parameters during early pregnancy stratified by GWG among normal weight women (N = 6,010).
| Variables | GWG (kg) | P for interaction | ||
|---|---|---|---|---|
| <11.5 (N = 1,244) β (95% CI) | 11.5~16.0 (N = 2,001) β (95% CI) | ≥16.0 (N = 2,765) β (95% CI) | ||
| TSH continuous | −9.61 (−39.36, 20.15) | −14.38 (−36.47, 7.72) | −10.76 (−30.31, 8.79) | 0.78 |
| TSH quintiles | 0.96 | |||
| Q1 | Reference | Reference | Reference | |
| Q2 | 0.30 (−63.35, 63.96) | 6.67 (43.46, 56.80) | −3.31 (−47.86, 41.24) | |
| Q3 | −34.15 (−99.30, 31.00) | 3.97 (−45.71, 53.80) | −14.85 (−59.14, 29.45) | |
| Q4 | −1.62 (−68.23, 64.98) | −9.31 (−59.64, 41.01) | −17.24 (−61.10, 26.61) | |
| Q5 | −20.88 (−87.36, 45.60) | −19.37 (−69.64, 30.37) | −23.78 (−67.91, 20.35) | |
| P for trend | 0.55 | 0.34 | 0.22 | |
| FT4 continuous | −289.70 (−508.44, −70.96) | −130.24 (−300.48, 40.00) | −222.39 (−370.34, −74.45) | 0.63 |
| FT4 quintiles | 0.45 | |||
| Q1 | Reference | Reference | Reference | |
| Q2 | 1.99 (−62.99, 66.98) | 0.003 (−0.05, 0.05) | 15.98 (−26.69, 58.65) | |
| Q3 | −41.44 (−107.71, 24.84) | −0.01 (−0.06, 0.04) | 1.45 (−42.05, 44.95) | |
| Q4 | −76.49 (−143.43, −9.56) | −0.01 (−0.06, 0.04) | −7.37 (−51.51, 36.78) | |
| Q5 | −56.01 (−121.80, 9.78) | −0.02 (−0.08, 0.03) | −61.90 (−106.14, −17.67) | |
| P for trend | 0.01 | 0.29 | 0.004 | |
| FT3 continuous | 28.59 (−27.00, 84.18) | 27.00 (−16.83, 70.83) | −5.00 (−42.63, 32.63) | 0.16 |
| FT3 quintiles | 0.11 | |||
| Q1 | Reference | Reference | Reference | |
| Q2 | −8.09 (−73.25, 57.07) | 13.45 (−37.26, 64.16) | −32.40 (−75.83, 11.03) | |
| Q3 | −22.96 (−89.76, 43.84) | 31.77 (−17.19, 80.74) | −14.95 (−58.54, 28.64) | |
| Q4 | 21.63 (−46.58, 89.84) | 22.05 (−27.75, 71.85) | −17.43 (−62.44, 27.59) | |
| Q5 | 18.48 (−45.75, 82.71) | 37.27 (−14.08, 88.62) | −15.33 (−59.24, 28.58) | |
| P for trend | 0.39 | 0.16 | 0.75 | |
a
Adjusted for maternal education, maternal height, maternal age, gestational age, parity, infant's sex, high risk pregnancy, and mode of delivery. Bold values are statistically significant.