Table 5.
Adjusted regression coefficients a for birth weight associated with maternal thyroid parameters during early pregnancy stratified by GWG among underweight women (N = 1,358).
| Variables | GWG (kg) | P for interaction | ||
|---|---|---|---|---|
| <12.5 (N = 218) β (95% CI) | 12.5~18.0 (N = 629) β (95% CI) | ≥18.0 (N = 511) β (95% CI) | ||
| TSH continuous | −28.88 (−88.42, 30.69) | −32.32 (−69.84, 5.18) | 8.98 (−36.66, 54.62) | 0.14 |
| TSH quintiles | 0.12 | |||
| Q1 | Reference | Reference | Reference | |
| Q2 | −84.88 (−214.02, 44.26) | −62.25 (−147.30, 22.80) | 13.23 (−87.12, 113.58) | |
| Q3 | −59.22 (−197.25, 78.82) | −31.96 (−112.30, 48.39) | 4.08 (−96.42, 104.59) | |
| Q4 | −92.62 (−232.62, 47.38) | −95.04 (−179.42, −10.66) | 5.52 (−95.98, 107.02) | |
| Q5 | −81.50 (−220.24, 57.23) | −63.96 (−147.76, 20.03) | 16.75 (−83.51, 117.00) | |
| P for trend | 0.29 | 0.09 | 0.82 | |
| FT4 continuous | −223.01 (−666.41, 220.39) | −128.40 (−426.45, 169.66) | −359.33 (−700.95, −17.72) | 0.14 |
| FT4 quintiles | 0.14 | |||
| Q1 | Reference | Reference | Reference | |
| Q2 | 53.41 (−84.30, 191.11) | 15.60 (−79.82, 111.02) | 0.86 (−106.23, 107.94) | |
| Q3 | 20.64 (−113.42, 154.69) | −63.94 (−160.69, 32.82) | 16.15 (−94.28, 126.57) | |
| Q4 | −50.88 (−191.75, 89.98) | −7.56 (−101.78, 86.66) | −27.59 (−135.27, 80.09) | |
| Q5 | −58.94 (−191.20, 89.98) | −18.90 (−112.74, 74.94) | −96.60 (−202.68, 9.49) | |
| P for trend | 0.15 | 0.58 | 0.04 | |
| FT3 continuous | 29.50 (−87.30, 146.29) | −12.07 (−87.87, 63.74) | 15.31 (−79.22, 109.84) | 0.80 |
| FT3 quintiles | 0.26 | |||
| Q1 | Reference | Reference | Reference | |
| Q2 | 34.63 (−86.28, 155.54) | −27.16 (−107.67, 53.36) | −30.87 (−127.31, 65.56) | |
| Q3 | 19.83 (−105.27, 144.93) | 20.43 (−59.71, 100.57) | 29.85 (−69.69, 129.40) | |
| Q4 | 60.87 (−74.26, 196.00) | −12.54 (−98.26, 73.19) | −8.14 (−113.60, 97.32) | |
| Q5 | −4.56 (−157.30, 148.18) | −29.97 (−117.21, 57.27) | 37.83 (−71.34, 146.99) | |
| P for trend | 0.31 | 0.69 | 0.40 | |
a
Adjusted for maternal education, maternal height, maternal age, gestational age, parity, infant's sex, high risk pregnancy, and mode of delivery. Bold values are statistically significant.