Table 3.
Potential prognostic factors for kidney outcome by univariate and multivariate COX regression analysis.
| Variable | Univariable analysis (N = 60) | aMultivariable analysis (N = 52) | ||
|---|---|---|---|---|
| P-value | HR (95% CI) | P-value | HR (95% CI) | |
| Gender (female) | 0.528 | 0.663 (0.185, 2.379) | - | - |
| Age | 0.151 | 1.026 (0.991, 1.063) | - | - |
| Hematuria (0 = none; 1 = microscopic; 2 = macroscopic) | 0.090 | 2.227 (0.883, 5.622) | - | - |
| Proteinuria (0 = none; 1 = non-nephrotic; 2 = nephrotic) | 0.327 | 1.566 (0.639, 3.839) | - | - |
| SCr on diagnosis (increased by 200 μmol/L) | <0.001 | 2.355 (1.598, 3.471) | 0.004 | 2.663 (1.372, 5.172) |
| Serum C3 (increased by 0.1g/L) (n = 52) | 0.002 | 0.608 (0.445, 0.830) | 0.040 | 0.689 (0.483, 0.984) |
| Kidney IgG staining >1+ | 0.271 | 1.803 (0.631, 5.154) | - | - |
| IgG deposit on TBM and/or Bowman's capsule | 0.272 | 0.555 (0.195, 1.585) | - | - |
| Kidney C3 staining intensity (increased by 1+) | 0.006 | 2.170 (1.252, 3.762) | 0.028 | 2.770 (1.115, 6.877) |
| Kidney C1q positive staining | 0.041 | 3.126 (1.045, 9.353) | 0.780 | 0.805 (0.175, 3.699) |
| Percentage of crescents (increased by 10%) | 0.009 | 1.258 (1.059, 1.494) | 0.775 | 0.940 (0.616, 1.435) |
| Combined with other GN | 0.364 | 1.711 (0.536, 5.459) | - | - |
| ACEIs/ARBs | 0.484 | 0.677 (0.227, 2.021) | - | - |
| Steroids | 0.340 | 1.703 (0.570, 5.087) | - | - |
| Cytotoxic drugs | 0.597 | 1.343 (0.450, 4.010) | - | - |
| Plasmapheresis | 0.019 | 4.692 (1.295, 17.005) | 0.849 | 0.749 (0.038, 14.796) |
a
Multivariable analysis was performed in a subgroup of 52 patients, of which the values of serum C3 were available at the presentation. Bold values represent P < 0.05.