TABLE 1.
HLA-I specific and non-HLA-I specific inhibitory receptors, their distribution and ligands.
| Molecule | CD | Cell distribution | Ligand | |
| HLA specific inhibitory receptors | KIR2DL1 | CD158a | NK cells, T cells | HLA-CK80 allotypes (HLA-C2 epitope) |
| KIR2DL2/3 | CD158b1/b2 | NK cells, T cells | HLA-CN80 allotypes (HLA-C1 epitope) HLA-B*46:01 and -B*73:01 | |
| KIR2DL5 | CD158f | NK cells, T cells | ? | |
| KIR3DL1 | CD158e1 | NK cells, T cells | HLA-A Bw4, HLA-B Bw4 | |
| KIR3DL2 | CD158k | NK cells, T cells | HLA-A*03 and -A*11, HLA-F | |
| KIR3DL3 | CD158z | NK cells, T cells | ? | |
| LILRB1/LIR-1/ILT2 | CD85j | NK cells, T cells, B cells, monocytes, DCs | HLA-G, various HLA-I allotypes | |
| NKG2A | CD159a | NK and T cells | HLA-E | |
| LAG-3 | CD223 | Activated NK cells, activated T cells, B cells, pDCs | HLA-II | |
| Non-HLA specific inhibitory receptors | PD-1 | CD279 | NK cells, T cells, B cells, myeloid cells | PD-L1, PD-L2 |
| TIM-3 | CD366 | NK cells, T cells, DCs, monocytes, macrophages, mast cells | Gal-9, PS, HMGB1, CEACAM1 | |
| TIGIT | NA | NK cells, T cells | CD155, CD112, CD113 | |
| Tactile | CD96 | NK cells, T cells | CD155, CD111 | |
| Siglec-7/p75/AIRM-1 | CD328 | NK cells, T cells, granulocytes, monocytes, | Sialic acid | |
| Siglec-9 | CD329 | NK cells, T cells, B cells, granulocytes, monocytes | Sialic acid | |
| KLRG1 | NA | NK cells, T cells | cadherins | |
| IRp60 | CD300a | NK cells, T cells, B cells, neutrophils, eosinophils, mast cells, pDC | phosphatidylserine (PS), phoshatidylethanolamine (PE) | |
| LAIR-1/p40 | CD305 | NK cells, T cells, B cells, monocytes, granulocytes, DCs, mast cells, macrophages, CD34+ hematopoietic progenitor cells, thymocytes | Collagen, C1q, surfactant protein D | |
| CEACAM-1 | CD66a | epithelial cells, various leukocytes | CEACAM-1, CEACAM-5 | |
| NKRP1A | CD161 | NK cells, T cells | LLT1 | |
| IAP | CD47 | NK cells, T cells, B cells, monocytes, macrophages, DCs, neutrophils | SIRP1a, TSP-1 | |