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. 2020 Sep 3;8:850. doi: 10.3389/fcell.2020.00850

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Copyright © 2020 Zhang, Hu and Yu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Related circular RNAs (circRNAs) in the pathogenesis of ocular neovascular diseases. (A) In corneal epithelial keratinocytes, circZNF609 regulates the function of epithelial cells and promote the ocular angiogenesis through miR-184-AKT/β-catenin/vascular endothelial growth factor (VEGF) network. (B) In vascular endothelial cells, networks of circ_0005015-miR-519d-3p-matrix metallopeptidase (MMP)-2/STAT3/X-linked inhibitor of apoptosis protein (XIAP), circHIPK3-miR-30a-3p-VEGFC/FZD4/WNT2, circZNF609-miR-615-5p-MEF2A, circDMNT3B-miR-20b-5p-BMP, and activin membrane bound inhibitor (BAMBI), and circZBTB44-miR-578-VEGFA/vascular cell adhesion molecule (VCAM)1 regulate the function of endothelial cells and the ocular angiogenesis. Circ_0005015, circHIPK3, and circZNF609 can promote angiogenesis and be upregulated under diabetes-related stresses, which is opposite to circDMNT3B. CircZBTB44 can promote angiogenesis and be upregulated under diabetes-related stresses. (C) In pericytes, networks of circPWWP2A-miR-579-angiopoietin1/occludin/sirtuin (SIRT)1 and circZNF532-miR-29a-3p-CSPG4/LOXL2/CDK2 regulate the function of pericytes and the ocular angiogenesis. CircPWWP2A and circZNF532 can inhibit the angiogenesis and maintain the normal vascular structure. CircPWWP2A is also packaged into exosomes and transported from pericytes to the endothelial cells.