Table 2.
Subgroup analyses for exploration of factors influencing heterogeneity in CSF T-SPOT assay.
| Variables | Category (number of studies) | Pooled sensitivity (95% CI) | I2 | Pooled specificity (95% CI) | I2 | Pooled diagnostic odds ratio (95% CI) |
|---|---|---|---|---|---|---|
| Design | Prospective (9) | 0.70 (0.64–0.77) | 60.1% | 0.85 (0.81–0.89) | 57.4% | 14.88 (8.86–24.99) |
| Retrospective (7) | 0.80 (0.75–0.84) | 86.5% | 0.90 (0.87–0.93) | 60.6% | 61.29 (24.53–153.10) | |
| TB burden | High TB prevalence (11) | 0.78 (0.74–0.82) | 82.1% | 0.89 (0.86–0.92) | 67.6% | 51.27 (25.47–103.20) |
| Intermediate TB prevalence (5) | 0.66 (0.55–0.75) | 46.2% | 0.85 (0.80–0.89) | 5.9% | 11.25 (6.35–19.93) | |
| Sample | >60 (10) | 0.76 (0.72–0.80) | 81.3% | 0.87 (0.84–0.90) | 70.2% | 29.20 (15.81–53.93) |
| ≤60 (6) | 0.76 (0.66–0.85) | 77.4% | 0.91 (0.86–0.95) | 12.1% | 30.29 (7.03–130.54) | |
| CSFMCs/well | 2.5 × 105 (11) | 0.73 (0.68–0.78) | 76.4% | 0.87 (0.84–0.90) | 52.1% | 19.51 (11.39–33.44) |
| ≤2.5 × 105 (5) | 0.82 (0.75–0.87) | 82.6% | 0.89 (0.84–0.93) | 75.9% | 84.63 (20.43–350.66) |
CSF, cerebrospinal fluid; CSFMCs, cerebrospinal fluid mononuclear cells; TB, tuberculosis; CI, confidence interval.