Table 3.
Weighted meta-regression to assess the effects of various factors on the diagnostic accuracy of CSF T-SPOT assay.
| Covariate | Coefficient | RDOR (95% CI) | P |
|---|---|---|---|
| Design | |||
| Prospective (9) | −1.528 | 0.22 (0.03–1.51) | 0.11 |
| Retrospective (7) | |||
| TB burden | |||
| High TB prevalence (11) | −0.045 | 0.96 (0.10–9.06) | 0.97 |
| Intermediate TB prevalence (5) | |||
| Sample | |||
| >60 (10) | −0.537 | 0.58 (0.14–2.38) | 0.41 |
| ≤60 (6) | |||
| CSFMCs/well | |||
| 2.5 × 105 (11) | −1.302 | 0.27 (0.04–1.75) | 0.15 |
| ≤2.5 × 105 (5) | |||
CSF, cerebrospinal fluid; RDOR, relative diagnostic odds ratio; TB, tuberculosis; CSFMCs, cerebrospinal fluid mononuclear cells; CI, confidence interval.