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. 2020 Sep 3;11:1001. doi: 10.3389/fneur.2020.01001

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Copyright © 2020 Mendes, Martins, Oliveira, Rocha, Cruz, Antunes, Abreu, Silva, Takiya, Pimentel-Coelho, Robba, Mendez-Otero, Pelosi, Rocco and Silva.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Expression of biologic markers associated with kidney damage. (A) Interleukin (IL)-6 mRNA levels; (B) Kidney injury molecule-1 (KIM-1) mRNA levels. Comparisons among all groups were done using the Kruskal–Wallis test, with significance accepted at p < 0.05. Boxes show the interquartile range (25–75th percentile), while whiskers encompass the range (minimum-maximum) and horizontal lines represent the median in 8 animals/group. Scatter plots are also presented. Relative gene expression was calculated as a ratio of average expression of each gene to the reference gene (36B4) and expressed as fold change relative to Saline group. * vs. Saline 0.9%; # vs. 5% ALB.