FIG 7.

Proteomic analysis of the A. fumigatus wild-type strain and shoA, msbA, and opyA null mutants exposed to caspofungin. (A) Number of proteins with increased (UP) and decreased (DOWN) abundance in the wild-type strain and the ΔshoA, ΔmsbA, and ΔopyA mutants when exposed to caspofungin 2 μg/ml for 1 h. (B) Venn diagrams comparing the abundances of proteins in the wild-type and each mutant strain. (C to F) A summary of the FunCat terms overrepresented with respect to increased or decreased abundance (adjusted P value of <0.05) in the wild-type strain exposed to caspofungin and compared to the control (C), in the ΔshoA mutant versus the wild-type strain posttransfer to caspofungin (D), in the ΔmsbA mutant versus the wild-type strain posttransfer to caspofungin (E), and in the ΔopyA mutant versus the wild-type strain posttransfer to caspofungin (F). For the full list, refer to Table S1.