Table 1.
Univariate and multivariate analyses.
| Features | Univariate analysis | Multivariate analysis (SRSI model) | Multivariate analysis (BALL model) | Multivariate analysis (SRSI + biological parameter model) | ||||
|---|---|---|---|---|---|---|---|---|
| HR (95% CI) | P | HR (95% CI) | P | HR (95% CI) | P | HR (95% CI) | P | |
|
Hemoglobin <110 g/L for women <120 g/L for men |
3.63 (1.87–7.05) | <0.0001 | 2.36 (1.15–4.84) | 0.02 | 2.19 (1.05–4.58) | 0.036 | 2.37 (1.15–4.89) | 0.019 |
| β2 M ≥ 5 mg/L | 3.98 (2.15–7.36) | <0.0001 | 2.25 (1.13–4.48) | 0.021 | 2.23 (1.12–4.46) | 0.023 | 2.23 (1.12–4.46) | 0.022 |
| LDH > ULN | 3.18 (1.73–5.87) | <0.0001 | 2.29 (1.21–4.33) | 0.011 | 2.21 (1.16–4.19) | 0.016 | 2.03 (1.05–3.94) | 0.035 |
| Time from the last therapy <24 months | 2.37 (1.01–5.6) | 0.049 | – | – | 1.51 (0.62–3.67) | 0.365 | – | – |
| Age >65 years | 0.66 (0.32–1.38) | 0.274 | – | – | – | – | – | – |
| 17p deletion positive | 2.07 (1.14–3.78) | 0.017 | – | – | – | – | 1.59 (0.85–2.96) | 0.15 |
| IGHV unmutated | 1.3 (0.93–1.74) | 0.13 | – | – | – | – | – | – |
HR hazard ratio, 95% CI 95% confidence interval, β2 M β2 microglobulin, ULN upper limit of normal.