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. 2020 Sep 16;10:15154. doi: 10.1038/s41598-020-72082-8

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Changes in the expression of biologic markers in the esophageal mucosa after eight weeks of proton pump inhibitor administration. Nine inflammatory markers (IFN-γ, IL-1β, IL-6, IL-8, IL-10, MCP1, NF-κB, RANTES, and TNF-α), four permeability markers (OCLN, ZO-1, CLDN-1, and CLDN-4), and two hypersensitivity markers (ASIC-3 and TRPV1) were assessed. The expression levels of IL-6, IL-8, NF-κB, TNF-α, CLDN-1, and TRPV1 showed statistically significant decrease after PPI administration. All nine inflammatory markers, except IL-1β, showed a tendency for decreased expression after PPI administration. Lines indicate the medians with interquartile ranges. P-values were indicated only if the comparisons were significant. PPI, proton pump inhibitor.