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. 2020 Sep 16;10:15154. doi: 10.1038/s41598-020-72082-8

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Correlations between the expression of biologic marker and the relative abundance of bacterial taxa (n = 10). The heatmap indicates the correlation coefficients between the expression of biologic markers and the relative abundance of bacterial taxa at the phylum level. Only statistically significant correlations are presented in this heatmap. The correlation was more common between bacterial taxa and other bacterial taxa. NF-κB, IL-1β, and IL-8 were correlated with esophageal Fusobacteria (γ = 0.68, P = 0.032), oropharyngeal Tenericutes (γ = 0.64, P = 0.048), and esophageal Spirochaetes (γ = 0.72, P = 0.018), respectively. γ, correlation coefficient.