Table 2.

Changes in symptom scores after proton pump inhibitor administration.

Variable	Baseline	Week 4	P-value (vs. baseline)	Week 8	P-value (vs. baseline)	P-value (vs. week 4)
PAGI-SYM (0–5)
Heartburn/regurgitation
Heartburn	1.85 ± 1.43	0.65 ± 0.93	< 0.001	0.54 ± 0.80	< 0.001	0.381
Regurgitation	2.18 ± 1.45	0.73 ± 0.93	< 0.001	0.50 ± 0.38	< 0.001	0.035
Nausea/vomiting	0.97 ± 1.09	0.32 ± 0.52	< 0.001	0.23 ± 0.66	< 0.001	0.396
Early satiety	1.49 ± 1.03	0.84 ± 0.72	< 0.001	0.59 ± 0.64	< 0.001	0.001
Bloating	1.35 ± 1.28	0.74 ± 0.91	< 0.001	0.48 ± 0.85	< 0.001	0.018
Upper abdominal pain	1.72 ± 1.46	0.76 ± 1.13	< 0.001	0.56 ± 0.85	< 0.001	0.166
Lower abdominal pain	0.85 ± 1.21	0.60 ± 1.00	0.069	0.45 ± 0.74	0.004	0.107
HAD (0–3)
Anxiety	0.76 ± 0.49	0.57 ± 0.42	< 0.001	0.50 ± 0.38	< 0.001	0.038
Depression	0.81 ± 0.44	0.67 ± 0.46	0.003	0.58 ± 0.44	< 0.001	0.019
Adherence rate (%)		97.5 ± 5.2		96.8 ± 5.8		0.435

PAGI-SYM, HAD, and adherence rate were presented as mean with standard deviation.

Adherence rate was defined as the number of drugs taken divided by the number of drugs to be taken.

PAGI-SYM, patient assessment of upper gastrointestinal symptom severity index; HAD, hospital anxiety and depression scale.