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. 2020 Sep 16;7:309. doi: 10.1038/s41597-020-00652-6

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — Overview of the datasets used in the study with a focus on the localization of naturally occurring ACE2 variants in the human population. (a) Venn diagram showing the variability of sequence variants among the 3 different datasets assembled in this study. (b) structure-based mapping of missense variants on the wild-type ACE2 in complex with the SARS-CoV-2 RBD, in the presence of the B⁰AT1 complex¹¹. Variants are distributed on the surface of the complex. (c) Measurement of distances of all mappable missense variants and report of the variants close to the different interfaces identified in the cryo-EM model of ACE2 in complex with the SARS-CoV-2 RBD, in the presence of the B⁰AT1 complex¹¹.