Online-only Table 1.
Variants identified in human population, mappable on the cryo-EM structure.
| #N | Variation | Haddock Score | vdW (a.u.) | Elec (a.u.) | Desol (a.u.) | BSA (Å2) |
| 0 | WT | −89.9 ± 5.2 | −54.7 ± 2.4 | −184.5 ± 9.3 | 1.7 ± 4 | 1729 ± 34.6 |
| 1 | E23K | −98 ± 11.1 | −54.8 ± 3.3 | −188.6 ± 24.2 | −5.5 ± 8.8 | 1740.2 ± 62.6 |
| 2 | K26R | −108.9 ± 5.1 | −57.8 ± 5.6 | −198.7 ± 10.8 | −11.4 ± 7.9 | 1762.8 ± 43.4 |
| 3 | E37K | −91.1 ± 5.2 | −55.1 ± 2.2 | −184.4 ± 17.5 | 0.9 ± 6.4 | 1737.9 ± 26.6 |
| 4 | F40L | −99.5 ± 9.5 | −57.2 ± 3.2 | −187.5 ± 20.7 | −4.8 ± 7.2 | 1763.7 ± 66.2 |
| 5 | S47P | −99.4 ± 3.5 | −53.8 ± 3.3 | −187.5 ± 14.3 | −8.1 ± 3.9 | 1729.1 ± 41.3 |
| 6 | N58D | −106.9 ± 6.2 | −56 ± 3.6 | −189.7 ± 39.9 | −13.1 ± 6.2 | 1724.2 ± 16.8 |
| 7 | N58H | −92 ± 8.1 | −52.1 ± 4 | −209.1 ± 10.1 | 2 ± 4.4 | 1739.9 ± 39 |
| 8 | N64K | −103.4 ± 2.1 | −53.9 ± 3.1 | −195.1 ± 7.6 | −10.5 ± 2.5 | 1746.1 ± 32.4 |
| 9 | M82I | −90.5 ± 6 | −53.6 ± 3.4 | −188.2 ± 19.5 | 0.8 ± 6.3 | 1708.7 ± 19.4 |
| 10 | Q86R | −93.2 ± 0.7 | −55 ± 1.9 | −198.7 ± 9.8 | 1.5 ± 2.5 | 1772.1 ± 23.6 |
| 11 | A99T | −110.3 ± 7.5 | −58.6 ± 3.1 | −183.7 ± 16.5 | −14.9 ± 4.3 | 1799.9 ± 28.7 |
| 12 | N103H | −96.2 ± 1.5 | −55.8 ± 2.3 | −201.9 ± 15.5 | 0 ± 6 | 1713.3 ± 43.9 |
| 13 | V107A | −94.9 ± 2.6 | −54.6 ± 2.6 | −204.8 ± 9.1 | 0.6 ± 3.8 | 1736.6 ± 18 |
| 14 | R115Q | −99.1 ± 4.9 | −56.9 ± 1.5 | −205.7 ± 9.8 | −1.1 ± 4.1 | 1766.2 ± 19.5 |
| 15 | R115W | −100.1 ± 8 | −54.9 ± 1.2 | −192.3 ± 22.1 | −6.7 ± 6.8 | 1742.6 ± 36 |
| 16 | P138L | −108.3 ± 10.9 | −54.8 ± 1.5 | −217.4 ± 13.7 | −10.1 ± 12.1 | 1735.6 ± 5.4 |
| 17 | C141Y | −98.6 ± 2.9 | −55.5 ± 1.9 | −176.1 ± 10.7 | −7.8 ± 3.5 | 1732.5 ± 35.8 |
| 18 | N154K | −89.8 ± 3.5 | −53.8 ± 0.7 | −179.1 ± 12.2 | −0.2 ± 6 | 1707 ± 13.2 |
| 19 | N159S | −100 ± 9.5 | −54.3 ± 2.1 | −208.4 ± 15.2 | −4.1 ± 7 | 1751.3 ± 50 |
| 20 | E171D | −97.8 ± 4.2 | −54.9 ± 0.9 | −210.7 ± 19.4 | −0.8 ± 4.9 | 1733.5 ± 56.3 |
| 21 | V184A | −101.6 ± 7.4 | −54.8 ± 2.9 | −200.5 ± 10 | −6.7 ± 10 | 1741.4 ± 45.1 |
| 22 | A191P | −98.9 ± 3.5 | −56.2 ± 2.2 | −193.9 ± 9.5 | −3.9 ± 5.2 | 1734.8 ± 68.5 |
| 23 | H195Y | −89.4 ± 2.5 | −56.6 ± 1 | −156.2 ± 21.9 | −1.5 ± 4.7 | 1748.7 ± 49.6 |
| 24 | D206G | −97.5 ± 2.8 | −56.9 ± 3.5 | −191.4 ± 10.9 | −2.3 ± 4.4 | 1745 ± 60.9 |
| 25 | G211R | −103 ± 2.5 | −58.5 ± 3.8 | −204.2 ± 18.1 | −3.6 ± 7 | 1816.3 ± 18 |
| 26 | D216E | −95.9 ± 5.4 | −55.2 ± 1.2 | −174.3 ± 22.7 | −5.8 ± 5.8 | 1731.3 ± 20.4 |
| 27 | Y217C | −89.8 ± 2.9 | −52.8 ± 2.2 | −202.8 ± 6.2 | 3.6 ± 3.3 | 1729.9 ± 16.8 |
| 28 | R219C | −101.5 ± 6 | −52.6 ± 1.8 | −215.2 ± 14.8 | −5.8 ± 2.2 | 1748.4 ± 21.3 |
| 29 | R219H | −98 ± 3.5 | −56.4 ± 2.4 | −207.1 ± 23.4 | −0.2 ± 3.6 | 1759.8 ± 84 |
| 30 | G220S | −99 ± 3.4 | −56.6 ± 1.6 | −191 ± 11.6 | −4.3 ± 3.5 | 1771.6 ± 26.9 |
| 31 | P235R | −97.7 ± 4 | −54 ± 1.2 | −187.3 ± 11.3 | −6.3 ± 5.1 | 1685.9 ± 23.8 |
| 32 | A251T | −97.6 ± 1.8 | −55.8 ± 1.5 | −209.1 ± 5.5 | 0 ± 0.9 | 1757.5 ± 9.2 |
| 33 | Y252C | −94.5 ± 6.9 | −52.8 ± 3.2 | −179.7 ± 19.2 | −5.8 ± 8.1 | 1711.6 ± 44.9 |
| 34 | S257N | −93 ± 2.2 | −56.6 ± 3.6 | −186 ± 18.5 | 0.8 ± 1.5 | 1734.3 ± 27.6 |
| 35 | P263S | −92.7 ± 6.3 | −56 ± 2.7 | −172.7 ± 31 | −2.2 ± 4.7 | 1753.6 ± 37 |
| 36 | M270V | −97.1 ± 1.7 | −56 ± 2.1 | −188 ± 5.5 | −3.6 ± 1.6 | 1762.9 ± 44.2 |
| 37 | V283F | −88.6 ± 2.4 | −54.6 ± 4.8 | −182 ± 12.9 | 2.4 ± 6.9 | 1739.8 ± 32.8 |
| 38 | K288T | −92.1 ± 2.6 | −56.2 ± 2.4 | −182.3 ± 14.5 | 0.5 ± 2.4 | 1719.6 ± 30.4 |
| 39 | I291K | −93.8 ± 2.7 | −53.5 ± 2.9 | −192.4 ± 17 | −1.8 ± 4.2 | 1732 ± 15.6 |
| 40 | D292V | −92.1 ± 1.3 | −56.2 ± 2.1 | −178.5 ± 19.3 | −0.2 ± 1.7 | 1715.7 ± 23.4 |
| 41 | D295G | −96.7 ± 9 | −57.2 ± 2.2 | −166.4 ± 30.9 | −6.2 ± 7.5 | 1759 ± 30.2 |
| 42 | M297L | −98.9 ± 8 | −56.6 ± 2.2 | −173.1 ± 5.4 | −7.7 ± 7.7 | 1699.3 ± 7 |
| 43 | M297I | −83.8 ± 7 | −55.4 ± 1.2 | −195.9 ± 9.9 | 10.8 ± 7.9 | 1715.3 ± 9.1 |
| 44 | V298A | −87.6 ± 4.6 | −55.9 ± 3 | −180.4 ± 34.9 | 4.4 ± 8.2 | 1714.8 ± 47.3 |
| 45 | D299G | −98 ± 2.4 | −53.7 ± 2.4 | −206.3 ± 17.3 | −3 ± 3.3 | 1739.8 ± 44.7 |
| 46 | E312K | −95.7 ± 2.7 | −57.4 ± 3.1 | −186 ± 18.4 | −1.1 ± 1.8 | 1794.4 ± 28.3 |
| 47 | G326E | −103.3 ± 4.8 | −58.1 ± 1.1 | −216.1 ± 10.3 | −2 ± 6.2 | 1838.4 ± 42.8 |
| 48 | E329G | −91.2 ± 4.5 | −56.8 ± 4.7 | −175.5 ± 11.2 | 0.7 ± 5.5 | 1721.3 ± 22.3 |
| 49 | M332L | −98.1 ± 1.1 | −54.4 ± 2.7 | −194.6 ± 4.2 | −4.8 ± 1.5 | 1760.8 ± 35.6 |
| 50 | T334M | −93.9 ± 5 | −54.6 ± 2.4 | −195.6 ± 19.2 | −0.2 ± 4.7 | 1761 ± 65.1 |
| 51 | N338S | −99.1 ± 5.7 | −56.8 ± 3.6 | −180.1 ± 3.8 | −6.3 ± 8.3 | 1751.2 ± 36.4 |
| 52 | K341R | −95.6 ± 5.9 | −55 ± 0.8 | −210.1 ± 13.5 | 1.4 ± 4.6 | 1760.2 ± 23.4 |
| 53 | G352V | −108.6 ± 4.6 | −58.3 ± 2.6 | −197.8 ± 16.1 | −10.8 ± 4.7 | 1792.5 ± 38.4 |
| 54 | D368N | −102.1 ± 2.3 | −56.1 ± 5 | −189.2 ± 5.3 | −8.1 ± 3.9 | 1721.9 ± 43.3 |
| 55 | E375D | −92.8 ± 2.2 | −51.8 ± 2.7 | −201.4 ± 19.4 | −0.7 ± 4.3 | 1721.6 ± 30.2 |
| 56 | M376T | −97.7 ± 2.8 | −54.2 ± 3.1 | −178.5 ± 22.3 | −7.8 ± 3.2 | 1701.4 ± 45.8 |
| 57 | G377V | −97.5 ± 4.2 | −55.2 ± 2.8 | −200.2 ± 18.3 | −2.3 ± 5.3 | 1755.8 ± 35.5 |
| 58 | H378R | −96.8 ± 4.7 | −54.1 ± 3 | −187.8 ± 14.3 | −5.1 ± 6.4 | 1715.6 ± 8.4 |
| 59 | M383T | −96.5 ± 5.4 | −55.5 ± 2.1 | −185.8 ± 7.6 | −3.9 ± 6.6 | 1697.7 ± 25.1 |
| 60 | Q388L | −106.1 ± 2.7 | −56.6 ± 2.6 | −191.2 ± 23.1 | −11.2 ± 3.9 | 1753.2 ± 21.4 |
| 61 | P389H | −90.4 ± 5 | −54.5 ± 1.4 | −184.2 ± 4.8 | 0.9 ± 5.1 | 1753.4 ± 57.2 |
| 62 | N397D | −98.7 ± 5.9 | −55.6 ± 1 | −213.1 ± 26.9 | −0.5 ± 6.7 | 1712.5 ± 58.7 |
| 63 | F400L | −94.7 ± 5.4 | −55.3 ± 2.5 | −194.2 ± 23.5 | −0.6 ± 8.1 | 1747.9 ± 10.7 |
| 64 | L410V | −102.3 ± 5.9 | −56.5 ± 2.2 | −191.2 ± 3.1 | −7.6 ± 7 | 1766.1 ± 14.7 |
| 65 | L418S | −97.5 ± 5.5 | −55 ± 4 | −194.5 ± 18.4 | −3.6 ± 10.5 | 1740.7 ± 55.9 |
| 66 | S420C | −97.6 ± 3.9 | −54.9 ± 2.4 | −212.7 ± 8.8 | −0.2 ± 4.9 | 1760.2 ± 16.6 |
| 67 | S420P | −97.6 ± 7.9 | −54.7 ± 3.8 | −220.5 ± 8.1 | 1.2 ± 5.7 | 1751.4 ± 25.6 |
| 68 | D427Y | −101 ± 4.2 | −58 ± 2.2 | −185.8 ± 15.8 | −5.9 ± 4.9 | 1739.2 ± 54 |
| 69 | N437S | −87.6 ± 3.5 | −56.5 ± 3.1 | −182.3 ± 15.7 | 5.3 ± 7.5 | 1738.5 ± 30.5 |
| 70 | T445M | −99 ± 7.2 | −55.8 ± 3.4 | −198.1 ± 17.5 | −3.6 ± 8.7 | 1756.9 ± 37.4 |
| 71 | I446M | −91.8 ± 8.2 | −54.4 ± 1.9 | −189.4 ± 18.6 | 0.4 ± 12.6 | 1744.2 ± 102.6 |
| 72 | V447F | −101.4 ± 7.7 | −59.2 ± 4 | −205.5 ± 21.3 | −1.1 ± 3 | 1772.5 ± 52.4 |
| 73 | G448E | −97 ± 3.1 | −53.9 ± 3.3 | −209.2 ± 20.8 | −1.3 ± 4.7 | 1774.8 ± 62.9 |
| 74 | M462I | −95.9 ± 5.1 | −55.4 ± 0.8 | −174.4 ± 23.8 | −5.6 ± 7 | 1733 ± 39.7 |
| 75 | E467K | −92.4 ± 1.6 | −56 ± 0.8 | −193.2 ± 10.5 | 2.2 ± 2.6 | 1757.3 ± 31.1 |
| 76 | I468V | −94 ± 1.9 | −55 ± 2.9 | −182.3 ± 18.9 | −2.5 ± 3.6 | 1705.7 ± 31.9 |
| 77 | M480V | −96 ± 1.9 | −55.1 ± 1.3 | −199.5 ± 30.8 | −1 ± 3.9 | 1730.8 ± 29.9 |
| 78 | R482Q | −98.3 ± 1.4 | −51.6 ± 2.6 | −191.6 ± 16.8 | −8.4 ± 6.8 | 1739.1 ± 46.2 |
| 79 | E483D | −104.6 ± 6.6 | −57.4 ± 2.4 | −185.2 ± 25 | −10.1 ± 8.3 | 1777.7 ± 24 |
| 80 | P492S | −104.7 ± 2.3 | −58 ± 4 | −189.3 ± 10.3 | −8.8 ± 2.6 | 1781.4 ± 34.9 |
| 81 | D494V | −99.9 ± 2.6 | −55.4 ± 3.5 | −207.2 ± 13.2 | −3.1 ± 8.1 | 1750.6 ± 15.8 |
| 82 | A501T | −97.3 ± 2.1 | −53.3 ± 1.4 | −171.8 ± 25.3 | −9.7 ± 4.8 | 1709.1 ± 23.6 |
| 83 | F504L | −99.8 ± 5.8 | −52 ± 1 | −202.6 ± 4.9 | −7.2 ± 5.8 | 1760.3 ± 28.6 |
| 84 | F504I | −91.9 ± 1.5 | −54.4 ± 4.3 | −189.8 ± 6.5 | 0.5 ± 4.4 | 1726.4 ± 10.9 |
| 85 | V506A | −89.8 ± 3.4 | −54.6 ± 1.2 | −184.2 ± 4.4 | 1.7 ± 4.6 | 1723.8 ± 22.2 |
| 86 | S511P | −92.3 ± 1.4 | −54 ± 2.7 | −189.7 ± 31.2 | −0.4 ± 9.6 | 1731.3 ± 46 |
| 87 | R514G | −103 ± 3.9 | −54.1 ± 2.2 | −196.2 ± 8 | −9.7 ± 5.3 | 1709.6 ± 24 |
| 88 | F523L | −97.8 ± 5.7 | −55.3 ± 2.4 | −210.5 ± 10.6 | −0.4 ± 4.8 | 1749.5 ± 60 |
| 89 | A532T | −103 ± 3.9 | −55.9 ± 1.8 | −201.9 ± 8.1 | −6.7 ± 3.5 | 1765.8 ± 40.5 |
| 90 | K541I | −104.3 ± 8.7 | −55 ± 3.5 | −189.7 ± 34.8 | −11.4 ± 5.1 | 1722.1 ± 41 |
| 91 | N546D | −91.1 ± 3.1 | −56.7 ± 2.3 | −190.8 ± 21.4 | 3.8 ± 5.7 | 1744.5 ± 18.8 |
| 92 | S547C | −93.9 ± 6.1 | −52.9 ± 3.9 | −197.2 ± 13.4 | −1.6 ± 4.6 | 1743.6 ± 40.8 |
| 93 | K553T | −97.2 ± 4.9 | −57.4 ± 2.3 | −205.9 ± 19.4 | 1.4 ± 4.7 | 1808.1 ± 36.6 |
| 94 | R559S | −96.7 ± 0.7 | −56.5 ± 0.9 | −195.8 ± 7.3 | −1 ± 2 | 1764.8 ± 57.3 |
| 95 | S563L | −101.2 ± 5.6 | −56.6 ± 3.2 | −196.5 ± 18.8 | −5.4 ± 6.5 | 1735.3 ± 46.4 |
| 96 | L570S | −94.4 ± 5.5 | −54.6 ± 3.7 | −177.8 ± 18.2 | −4.3 ± 1.9 | 1698.6 ± 19.2 |
| 97 | R582S | −108.9 ± 4.7 | −57.8 ± 1.2 | −204.4 ± 10.2 | −10.2 ± 3.2 | 1789.1 ± 34.8 |
| 98 | R582K | −90.5 ± 6.1 | −58.4 ± 2.6 | −174.3 ± 3.8 | 2.8 ± 4.2 | 1734.7 ± 4.4 |
| 99 | N586Y | −94.8 ± 3.3 | −53.5 ± 2.6 | −191.7 ± 6.8 | −3 ± 4.2 | 1745.2 ± 32.4 |
| 100 | T593N | −95.5 ± 2.6 | −55.9 ± 0.8 | −199.9 ± 19.9 | 0.3 ± 4.4 | 1742.9 ± 42.5 |
| 101 | L595V | −93.1 ± 1.6 | −57.4 ± 2.9 | −204.9 ± 9.3 | 5.3 ± 4.5 | 1725.9 ± 55.1 |
| 102 | D597E | −96 ± 4.4 | −53 ± 4.4 | −184 ± 16.1 | −6.2 ± 7.7 | 1742.6 ± 73.1 |
| 103 | S607G | −92.8 ± 1.5 | −52.4 ± 3.1 | −185.1 ± 8.5 | −3.4 ± 1.7 | 1708.5 ± 46.4 |
| 104 | D609N | −95 ± 1.9 | −56.4 ± 1.2 | −183.9 ± 12.6 | −1.8 ± 3.8 | 1753.1 ± 33.6 |
| 105 | A614S | −93.5 ± 2.3 | −57 ± 2.4 | −194.9 ± 28.1 | 2.4 ± 5 | 1777 ± 55.5 |
| 106 | A614T | −103.5 ± 1.1 | −53.9 ± 1.7 | −195.1 ± 20.1 | −10.6 ± 3.5 | 1746.8 ± 15.8 |
| 107 | N638S | −101.8 ± 3.9 | −53.8 ± 3.2 | −197.3 ± 17.4 | −8.5 ± 5.4 | 1748.8 ± 27.9 |
| 108 | Y654S | −99.2 ± 6.8 | −56.4 ± 2.5 | −203.5 ± 10.8 | −2.2 ± 5 | 1707.9 ± 14.3 |
| 109 | E667V | −91.4 ± 3.6 | −53.7 ± 1.6 | −174.2 ± 23.1 | −2.9 ± 7.2 | 1761.9 ± 30.6 |
| 110 | V670A | −94.2 ± 4.8 | −57.9 ± 1.5 | −176.7 ± 16.3 | −0.9 ± 6.4 | 1741 ± 48.6 |
| 111 | R671Q | −99.9 ± 5.6 | −54.9 ± 2.5 | −170.7 ± 16.2 | −10.9 ± 5.9 | 1711 ± 41.7 |
| 112 | R671P | −98.8 ± 3.5 | −52.7 ± 4.6 | −192.6 ± 21.7 | −7.5 ± 4.1 | 1728.5 ± 63.4 |
| 113 | V672L | −99.4 ± 3.4 | −54.1 ± 2.2 | −182.4 ± 17.6 | −8.8 ± 3.3 | 1737.4 ± 60.6 |
| 114 | V672A | −94.7 ± 1.7 | −55.9 ± 2.3 | −195.2 ± 10.2 | 0.2 ± 5.3 | 1767.8 ± 41 |
| 115 | A673G | −99.5 ± 10.9 | −56.1 ± 2.2 | −178.5 ± 47 | −7.7 ± 9 | 1757.9 ± 58.2 |
| 116 | K689E | −99.4 ± 4.3 | −53.3 ± 1.3 | −191.1 ± 23 | −7.9 ± 4 | 1731 ± 50.3 |
| 117 | S692P | −97.4 ± 7.3 | −52.8 ± 2.5 | −211.8 ± 17 | −2.2 ± 4.1 | 1743.1 ± 41 |
| 118 | D693H | −96.9 ± 7.1 | −55 ± 2.2 | −194 ± 23.1 | −3.1 ± 5.9 | 1737.1 ± 27.7 |
| 119 | P696T | −97.5 ± 7.1 | −53.2 ± 1.6 | −204.5 ± 7 | −3.4 ± 6.1 | 1724.8 ± 32.5 |
| 120 | R697G | −95.6 ± 3.2 | −54.7 ± 2.4 | −191.7 ± 11.3 | −2.6 ± 1.5 | 1729.6 ± 26.5 |
| 121 | V700I | −92.3 ± 5.1 | −54 ± 0.9 | −178.6 ± 11.1 | −2.5 ± 3 | 1704.5 ± 45.7 |
| 122 | R705S | −99.1 ± 4.7 | −54.3 ± 4.8 | −193.1 ± 14.2 | −6.2 ± 7.8 | 1708.9 ± 23.1 |
| 123 | R708W | −101.4 ± 4.9 | −53.9 ± 4 | −196.2 ± 11.3 | −8.2 ± 3 | 1810.3 ± 38.6 |
| 124 | S709R | −97 ± 4.1 | −57.4 ± 3.1 | −203.7 ± 2.9 | 1.2 ± 3.8 | 1763.4 ± 22.8 |
| 125 | R710C | −98.5 ± 1.8 | −55.8 ± 2.4 | −202.2 ± 15.2 | −2.3 ± 5.7 | 1791.5 ± 46.3 |
| 126 | R710H | −95.8 ± 5.6 | −53.5 ± 2.2 | −172.2 ± 8.9 | −7.9 ± 4.2 | 1694.5 ± 24 |
| 127 | R716H | −105.2 ± 4.5 | −54.1 ± 3 | −195.6 ± 24.9 | −11.9 ± 1.3 | 1761.4 ± 64.8 |
| 128 | R716C | −96.1 ± 4.4 | −56 ± 1.2 | −177.5 ± 12.1 | −4.6 ± 2.3 | 1725.1 ± 19.9 |
| 129 | N720D | −97 ± 1.8 | −53.7 ± 2.2 | −189.3 ± 5 | −5.5 ± 2.7 | 1743.2 ± 31.8 |
| 130 | N720S | −102.2 ± 6.3 | −54.5 ± 3.4 | −196 ± 22.5 | −8.5 ± 12.9 | 1783.9 ± 45 |
| 131 | L722P | −99.9 ± 4.8 | −55.6 ± 4.1 | −175.3 ± 27.9 | −9.2 ± 5.6 | 1724.6 ± 18.3 |
| 132 | P729L | −88.6 ± 3.2 | −57.5 ± 2.7 | −186 ± 18.9 | 6.2 ± 6.3 | 1749.2 ± 45.5 |
| 133 | L731F | −94.2 ± 1.7 | −55.3 ± 3.8 | −179.1 ± 19.1 | −3.2 ± 1.8 | 1708.6 ± 47.4 |
| 134 | S740F | −93.5 ± 4.1 | −54.7 ± 2.3 | −191.6 ± 20.5 | −0.5 ± 6.3 | 1750.8 ± 25.1 |
| 135 | S740P | −96.7 ± 4.5 | −52.6 ± 5.6 | −201 ± 12.8 | −3.9 ± 6.4 | 1759 ± 49 |
| 136 | I741V | −99.4 ± 11.5 | −55.7 ± 3.7 | −210.7 ± 6.9 | −1.6 ± 10 | 1724.8 ± 73.3 |
| 137 | V745I | −89.2 ± 2.1 | −53.9 ± 2.7 | −180.1 ± 6.3 | 0.7 ± 3.5 | 1710.7 ± 64.2 |
| 138 | V755A | −101.6 ± 2.1 | −56.2 ± 2.1 | −188.1 ± 14.8 | −7.8 ± 4.3 | 1739.8 ± 34.9 |
| 139 | D767H | −90.2 ± 9.3 | −57.2 ± 3.1 | −193.8 ± 10.7 | 5.8 ± 7.3 | 1734.3 ± 31.7 |
| 140 | R768W | −103 ± 5.4 | −57.2 ± 2.5 | −174 ± 40 | −11 ± 7.8 | 1766.6 ± 28.5 |
Table includes energetic calculations with HADDOCK. vdW–van der Waals interaction score; Elec–electrostatic interaction score; Desol–desolvation score; BSA–buried surface area; a.u.–arbitrary units of energy. Bold entries include variants within 10 Å of the ACE2-S protein interface.