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. 2020 Sep 16;11(9):763. doi: 10.1038/s41419-020-02945-5

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — a Flow cytometry analysis for the ratio of F4/80⁺CD206⁺ in RAW264.7 cells after treatment with IL-4. b Level of MM2P following the induction of M2 polarization at the indicated time. c The effect of sh-MM2P#1/2 transfection on the expression of MM2P in IL-4-induced M2 macrophages was measured by RT-qPCR. d Pictures of flow cytometry of F4/80⁺CD206⁺ cells and quantification of F4/80⁺CD206⁺ cell ratio under MM2P depletion in IL-4-induced cells. e RT-qPCR data for the levels of M2-related genes (Fizz-1, Arg1, YM1, MRC1, PPAR-γ) under the treatment of IL-4 with MM2P depletion in RAW264.7 cells. f Western blot for the total and phosphorylated STAT1, STAT6, and STAT3 in RAW264.7 cells treated with IL-4. g IF staining for the fluorescence intensity of p-STAT3 under IL-14 stimulation, as well as depletion of MM2P. Scale bar = 20 μm. **P < 0.01. Error bars are said to express as mean ± SD of three independent experiments in triplicates.