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. 2020 Sep 16;11(9):763. doi: 10.1038/s41419-020-02945-5

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — Chondrocytes were cultured in conditioned medium (CM) of IL-4/IL-13-induced M2 macrophages with indicated transfections. a RT-qPCR data of chondrogenic-specific genes Col2a1, Acan, and SOX9, as well as dedifferentiation-related gene Col1a1 of each group. b, c The production of sGAG and Collagen II in chondrocytes. d TEM and nanoparticle tracking analysis (NTA) analysis of exosomes from IL-4/IL-13-induced M2 macrophages. The exosome markers CD9, CD63, and CD81 were detected by western blot. e Levels of Col2a1, Acan, SOX9, and Col1a1 in chondrocytes after the incubation with exosomes from IL-13/IL-4-induced M2 macrophages with MM2P silence. f, g The production of sGAG and Collagen II in each group. **P < 0.01. The error bar expressed as mean ± SD of three independent experiments in triplicates.