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. 2020 Sep 16;10:15183. doi: 10.1038/s41598-020-72197-y

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Treatment with L. reuteri is protective in EAE. (A) Mice fed with L. reuteri present with lower clinical scores than Broth control (Wilcoxon matched-pairs signed-rank test: p-value = 0.0132, n = 10 per group). (B) qPCR with Lactobacillus specific primers revealed that abundance of L. reuteri is elevated in mice fed with supplemented diet 20 dpi (Paired t-tests at − 1 and 20 dpi: P-values = 0.9716 and 0.0054, n = 10 per group).