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. 2020 Sep 3;11:1235. doi: 10.3389/fphar.2020.01235

Figure 4.

Figure 4

Anti-fibrotic effects of CCN5 in high Ang II-induced hypertensive heart failure at 28 weeks. (A) Representative Masson staining of myocardial tissue from different groups at 24 and 28 weeks. Scale bar 100 μm. (B) Quantification of CVF from different groups at 24 and 28 weeks. * P < 0.05 vs. control, # P < 0.05 vs. model. (C) Western blot analysis of Col Ia and Col IIIa from different groups at 24 and 28 weeks. Quantification of Col Ia and Col IIIa in SHRs or treated by enalapril at 24 and 28 weeks. *P < 0.05 vs. control, # P < 0.05 vs. model. (D) Relative expression of CCN5, α-SMA, and TGF-β1 in SHRs or treated by enalapril at 24 and 28 weeks. * P < 0.05 vs. control, # P < 0.05 vs. model.