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. 2020 Sep 16;11:4659. doi: 10.1038/s41467-020-18397-6

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — a The chemical structure of GSK3008348 with full chemical name: (S)-3-(3-(3,5-dimethyl-1H-pyrazol-1-yl)phenyl)-4-(R)-3-(2-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)ethyl)pyrrolidin-1-yl)butanoic acid). b Docked GSK3008348 (orange) in a homology model of αvβ6 based on αvβ3 X-ray (1L5G) composed of α-subunit (magenta) and β-subunit (gray). c Solubility and key pharmacokinetic properties for GSK3008348 are also shown. SLF, simulated lung fluid.