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. 2020 Sep 16;11:4659. doi: 10.1038/s41467-020-18397-6

Fig. 2. High affinity and selectivity of GSK3008348 for the αvβ6 integrin.

Fig. 2

a Competition binding curves of GSK3008348 against the RGD integrins (mean ± SEM; n = 4). b pKI affinity or pIC50 values (αIIbβ3 only) for GSK3008348 against the RGD integrins with fold-selectivity for αvβ6 (mean ± SEM; n = 4–6). c Representative saturation binding curves for [3H]GSK3008348 in normal and IPF human lung tissue (duplicate points shown ± min/max). d Quantification of total levels of αvβ6 levels in normal and IPF human lung tissue (Box and whisker plot shows median, first and third quartiles, and max/min values; six donors per group). Source data are provided as a Source Data file.