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. 2020 Sep 16;11:4659. doi: 10.1038/s41467-020-18397-6

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — a Mice were treated with GSK3008348 prior to bleomycin challenge and the effect of GSK3008348 on the b collagen biomarkers hydroxyproline and c C3M in lung tissue (mean ± SEM; n = 6–10 animals per group). Levels of pSmad2 in d BAL cells and e βIG-H3, PAI-1 BAL fluid d in normal and IPF patient populations (mean ± SEM; 6–18 donors). The effect of GSK3008348 on PD biomarkers of TGFβ-activation in f lung tissue (pSmad2) and g BALF (βIG-H3 and PAI-1) in bleomycin-treated mice (mean ± SEM; n = 6–10 animals per group). All statistical analysis completed by ANOVA with Fisher’s LSD post test. Sal/Veh Saline/Vehicle, Bleo/Veh Bleomycin/Vehicle. Source data are provided as a Source Data file.