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. 2020 Sep 16;11:4659. doi: 10.1038/s41467-020-18397-6

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 7 — a Therapeutic dosing protocol. b Levels of collagen biomarker hydroxyproline in lung tissue from saline or bleomycin-treated mice in response to i.n. dosing with vehicle or GSK3008348 (mean ± SEM; n = 7–13 animals per group). c H&E and Sirius Red staining in representative lung sections from saline or bleomycin-treated mice (n = 4 animals per group). Scale bars are 100 µm. Statistical analysis completed by ANOVA with Fisher’s LSD post test. b.i.d., twice daily; Sal/Veh Saline/Vehicle, Bleo/Veh Bleomycin/Vehicle. Source data are provided as a Source Data file.