Table 2.
Information concerning patients with liver injury.
| Gender, age, circumstances | Paracetamol taken dose | Paracetamol serum concentration | Clinical signs | AST/ALT rates | Treatment | Evolution |
|---|---|---|---|---|---|---|
| Female, 15 year-old, voluntary poisoning by paracetamol/codeine | 38 g | 107.3 mg/L at 5 h post-ingestion. 6.7 mg/L at 48 h post-ingestion | Dizziness, vomiting and abdominal pain | AST : 91 IU/L ALT : 169 IU/L | Activated charcoal, oral NAC | Favorable |
| Female, 26 months, accidental exposure to paracetamol | NIP | 2.4 mg/L on day 10 post-ingestion | Altered state of consciousness, hepatomegaly on palpation, sub-jaundice, hematemesis, hypoglycemia, hepatic encephalopathy, convulsions | 100 x ULN | Ventilation, fentanyl, diazepam | Died after cardiac arrest |
| Female, 2 year-old, accidental exposure of paracetamol and amoxicillin | 1.5 g | 0.6 mg/L at 2 h post-ingestion | Liver injury | 4 x ULN | Oral NAC | Favorable |
| Male, 26 year-old, hypertensive patient, suspicion of paracetamol poisoning | NIP | 0.8 mg/L (delay post-ingestion not precised) | Edema, palpebral epistaxis, coma post-anoxic following a cardioresp arrest, fever, suspicious hepatic encephalithy | NIP | Gastric lavage, hypnovel, fentanyl | Died few days after admission |
| Male, 34 year-old, poly-drug voluntary poisoning : risperidone, ibuprofen, paracetamol/triprolidine/pseudoephedrine, levomepromazine, Nebivolol, etc.) | NIP | 8.9 mg/L (delay post-ingestion not precised) Presence of amitriptyline and phenothiazines in urine |
Cyanose, coma carus, collapse | NIP | Not received | Died after cardiac arrest |
| Pregnant female, 20 year-old, voluntary poisoning by paracetamol, anti-inflammatory, haloperidol, bleach cleaning solution | NIP | The dosage of paracetamol in serum has not been done | Agitation, polypnea, blurred vision, hearing loss, hypotonic diuresis | NIP | NIP | Mydriasis, hemorrhage and convulsions then Death |
| Male, 28 year-old, HIV positive, suspicion of paracetamol poisoning | NIP | Absence of paracetamol in serum | Agitations, hepatic encephalopathy, acute liver failure | NIP | Not received | Died 3 days after admission |
| Female, 10 year-old, therapeuticoverdose of paracetamol and acetylsalycilic acid | 300 mg every 4 h for 2 days | The dosage of paracetamol in serum has not been done. Presence of paracetamol and acetylsalycilic acid in urine | Hematemesis, hemorrhagic hepatitis | NIP | NIP | Favorable |
NIP:No Informations Provided.