Figure 4.

Binding of iRGD-exo to NPC Cell Lines In Vitro and Targeting of iRGD-exo In Vivo

(A) Exosomes and the targeting ability that localized the cell membrane and cytoplasm of HONE1 or HONE1-EBV cells with confocal microscopy images. Original magnification, ×630; scale bar, 10 μm. (B) Ex vivo fluorescence imaging of various major organs from nude mice bearing HONE1-EBV tumors. The sequence of organs from top to bottom is as follows: brain, tumor, heart, spleen, kidney, lung, liver. Results are mean ± SD, n = 5. (C) Various organs from mice treated as described in (B) were detected with hematoxylin and eosin (H&E) staining.