Figure 1. The histone methylation protein attached to N-terminal of H3; in unmethylated form it leads to start the transcription.

In the presence of DNMT that methylated the H3 of the histone resulted in the de novo methylation of DNA. The link of H3K9 with methylation of histone is carried out in the formation of complex of DNMT and UHRF, which resulted in repression of transcription. Abbreviation: UHRF, ubiquitin-like, containing PHD and RING finger domains, 1.