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. 2020 Sep 16;40(9):BSR20192095. doi: 10.1042/BSR20192095

Figure 2. The effects of miR-197 on cell proliferation, migration, and inflammation in chondrocytes.

Figure 2

(A) Chondrocytes were transfected with miR-197 mimics, mimics control, miR-197 inhibitors, and inhibitors control for 48 h, and the expression levels of miR-197 were detected. (B) MTT assay reveal that overexpression of miR-197 promoted the proliferation of chondrocytes, while down-regulation of miR-197 suppressed chondrocytes growth. (C) Transwell assay showed that miR-197 mimics facilitated the migration of chondrocytes, whereas miR-197 inhibitors induced the opposite effects; scale bar: 100 μm. (D) ELISA assay analysis of the concentration of IL-1β, IL-6, and TNF-α in chondrocytes after miR-197 overexpression and knockdown. The data were presented as the means ± SD from three independent experiments in triplicate.