Table 1. GO and KEGG pathway enrichment analysis of DEGs in the PAH samples.
| Term | Description | Count | P-value |
|---|---|---|---|
| Up-regulation | |||
| GO:0048285 | Organelle fission | 47 | 4.77E-15 |
| GO:0000280 | Mitotic nuclear division | 44 | 5.72E-13 |
| GO:0007059 | Chromosome segregation | 39 | 5.60E-13 |
| GO:0005874 | Microtubule | 35 | 8.74E-08 |
| GO:0005819 | Spindle | 33 | 1.10E-08 |
| GO:0098687 | Chromosomal region | 32 | 3.82E-08 |
| GO:0016887 | ATPase activity | 50 | 4.22E-15 |
| GO:0050839 | Cell adhesion molecule binding | 38 | 8.53E-07 |
| GO:0015631 | Tubulin-binding | 30 | 4.84E-07 |
| hsa05168 | Herpes simplex virus one infection | 114 | 2.44E-07 |
| hsa05412 | Arrhythmogenic right ventricular cardiomyopathy | 25 | 7.28E-05 |
| hsa01212 | Fatty acid metabolism | 20 | 0.000113535 |
| Down-regulation | |||
| GO:0046777 | Protein autophosphorylation | 19 | 0.000180252 |
| GO:0007051 | Spindle organization | 17 | 2.86E-05 |
| GO:0090734 | Site of DNA damage | 8 | 0.001801353 |
| GO:0097431 | Mitotic spindle pole | 5 | 0.001260684 |
| GO:0005178 | Integrin binding | 14 | 9.05E-05 |
| GO:0003725 | Double-stranded RNA binding | 9 | 0.000655078 |
| hsa01212 | Fatty acid metabolism | 11 | 0.001127558 |
| hsa01524 | Platinum drug resistance | 13 | 0.000232003 |
Abbreviations: DEG, differentially expressed gene; GO, Gene Ontology; KEGG, Kyoto Encyclopedia of Genes and Genomes; PAH, pulmonary arterial hypertension.