| 1 |
SMC4 |
Structural maintenance of chromosomes 4 |
SMC4 potentially promote response to innate inflammatory immune [23]. |
| 2 |
TOP2A |
DNA topoisomerase II alpha |
TOP2A decatenate intertwined DNA during anaphase to allow chromosome segregation to occur before cell division [33]. |
| 3 |
SMC2 |
Structural maintenance of chromosomes 2 |
SMC2 involving in chromosome segregation and stability chromosomal [20]. |
| 4 |
KIF11 |
Kinesin family member 11 |
Overexpression of KIF11during mitosis results in premature separation of sister chromatids and an uneven distribution of chromosomes [28]. |
| 5 |
KIF23 |
Kinesin family member 23 |
KIF23 plays an essential role in the bundling and transport of microtubules to specific intracellular locations in different cells at specific time points [34]. |
| 6 |
ANLN |
Anillin actin-binding protein |
ANLN is an F-actin binding protein that modulates podocyte cell motility and interacts with the phosphoinositide 3-kinase (PI3K) pathway via the slit diaphragm adaptor protein CD2-associated protein (CD2AP) [32]. |
| 7 |
ARHGAP11A |
Rho GTPase activating protein 11A |
ARHGAP11A dynamically regulated colon cancer cell motility and invasion and directly interacted with p53 tetramerization domain to exhibit a Rho-independent role in cancer [27]. |
| 8 |
SMC3 |
Structural maintenance of chromosomes 3 |
Smc3 acetylation stabilizes cohesin association with chromosomes, and its deacetylation by Hos1 in anaphase allows reuse of Smc3 in the next cell cycle [35]. |
| 9 |
SMC6 |
Structural maintenance of chromosomes 6 |
Smc5–Smc6 play an essential role in cellular processes such as genome replication, mitotic and meiotic chromosome segregation, DNA repair [30]. |
| 10 |
RAD50 |
RAD50 double-strand break repair protein |
Homologs of Rad50 and Mre11 form Mre112-Rad50 hetero-tetramers, where two Rad50 ATP-binding cassette nucleotide-binding domains and a Mre11 nuclease dimer assemble as a catalytic head module that binds and cleaves DNA [22]. |
