Table 3. Meta-analysis results.
| Genetic model | Category | n | Model | OR (95% CI) | P | Heterogeneity | Begg’s test | Egger’s test | |
|---|---|---|---|---|---|---|---|---|---|
| I2 | P | P | P | ||||||
| Homozygote (TT vs. CC) | Overall | 14 | R | 0.740 [0.555; 0.987] | 0.041 | 47.5% | 0.029 | 0.059 | 0.121 |
| Asian | 6 | R | 0.599 [0.275; 1.303] | 0.196 | 61.2% | 0.035 | 0.806 | 0.747 | |
| Caucasian | 7 | F | 0.920 [0.764; 1.110] | 0.384 | 7.7% | 0.370 | 0.072 | 0.115 | |
| African | 1 | F | 0.147 [0.025; 0.870] | 0.035 | - | - | - | - | |
| CHD | 3 | F | 1.006 [0.741; 1.364] | 0.972 | 0.0% | 0.836 | 1.000 | - | |
| ACS | 2 | F | 1.002 [0.753; 1.333] | 0.990 | 0.0% | 0.542 | 1.000 | - | |
| CAD | 9 | R | 0.545 [0.336; 0.884] | 0.014 | 49.6% | 0.044 | 0.602 | 0.651 | |
| HB | 9 | R | 0.474 [0.255; 0.880] | 0.018 | 50.6% | 0.048 | 0.711 | 0.814 | |
| PB | 5 | F | 0.963 [0.796; 1.165] | 0.696 | 0.0% | 0.860 | 0.086 | 0.080 | |
| PCR-RFLP | 7 | F | 0.420 [0.253; 0.698] | 0.001 | 39.1% | 0.145 | 1.000 | 0.709 | |
| Taqman | 4 | F | 0.963 [0.783; 1.186] | 0.725 | 44.4% | 0.145 | 0.089 | 0.151 | |
| PCR | 3 | F | 0.850 [0.577; 1.252] | 0.411 | 0.0% | 0.613 | 0.296 | 0.077 | |
| Heterozygote (CT vs. CC) | Overall | 14 | R | 0.883 [0.765; 1.031] | 0.115 | 61.1% | 0.001 | 0.063 | 0.441 |
| Asian | 6 | R | 0.786 [0.599; 1.031] | 0.082 | 59.5% | 0.030 | 0.707 | 0.856 | |
| Caucasian | 7 | F | 0.994 [0.898; 1.101] | 0.910 | 37.2% | 0.145 | 1.000 | 0.790 | |
| African | 1 | F | 0.321 [0.144; 0.715] | 0.005 | - | - | - | - | |
| CHD | 3 | F | 0.997 [0.850; 1.168] | 0.966 | 0.0% | 0.747 | 1.000 | 0.707 | |
| ACS | 2 | F | 0.961 [0.824; 0.715] | 0.614 | 9.5% | 0.293 | 1.000 | - | |
| CAD | 9 | R | 0.804 [0.605; 1.121] | 0.131 | 72.6% | 0.000 | 0.251 | 0.675 | |
| HB | 9 | R | 0.779 [0.574; 1.056] | 0.108 | 71.5% | 0.000 | 0.466 | 0.848 | |
| PB | 5 | F | 0.986 [0.888; 1.094] | 0.788 | 0.0% | 0.929 | 1.000 | 0.725 | |
| PCR-RFLP | 7 | R | 0.760 [0.529; 1.092] | 0.138 | 72.5% | 0.001 | 0.764 | 0.541 | |
| Taqman | 4 | F | 0.978 [0.871; 1.099] | 0.712 | 14.4% | 0.320 | 0.734 | 0.444 | |
| PCR | 3 | F | 1.006 [0.838; 1.208] | 0.947 | 0.0% | 0.643 | 1.000 | 0.421 | |
| Dominant (TT + CT vs. CC) | Overall | 14 | R | 0.856 [0.725; 1.010] | 0.066 | 68.3% | 0.000 | 0.051 | 0.361 |
| Asian | 6 | R | 0.772 [0.570; 1.044] | 0.093 | 68.6% | 0.007 | 0.707 | 0.898 | |
| Caucasian | 7 | F | 0.984 [0.893;1.085] | 0.752 | 46.7% | 0.081 | 0.764 | 0.996 | |
| African | 1 | F | 0.293 [0.135; 0.636] | 0.002 | - | - | |||
| CHD | 3 | F | 0.998 [0.857; 1.162] | 0.979 | 0.0% | 0.830 | 1.000 | 0.739 | |
| ACS | 2 | F | 0.966 [0.834; 1.120] | 0.649 | 22.0% | 0.258 | 1.000 | - | |
| CAD | 9 | R | 0.764 [0.566; 1.032] | 0.079 | 77.1% | 0.000 | 0.348 | 0.649 | |
| HB | 9 | R | 0.745 [0.538; 1.031] | 0.076 | 76.4% | 0.000 | 0.466 | 0.802 | |
| PB | 5 | F | 0.983 [0.889; 1.086] | 0.730 | 0.0% | 0.923 | 0.806 | 0.922 | |
| PCR-RFLP | 7 | R | 0.734 [0.503; 1.072] | 0.109 | 75.9% | 0.000 | 0.764 | 0.529 | |
| Taqman | 4 | F | 0.977 [0.874; 1.091] | 0.677 | 46.0% | 0.136 | 0.734 | 0.326 | |
| PCR | 3 | F | 0.988 [0.828; 1.180] | 0.898 | 0.0% | 0.527 | 0.296 | 0.346 | |
| Recessive (TT vs. CT + CC) | Overall | 14 | F | 0.881 [0.745; 1.041] | 0.136 | 26.0% | 0.182 | 0.100 | 0.103 |
| Asian | 6 | F | 0.682 [0.435; 1.068] | 0.094 | 47.1% | 0.109 | 0.806 | 0.781 | |
| Caucasian | 7 | F | 0.932 [0.778; 1.117] | 0.448 | 0.0% | 0.529 | 0.016 | 0.031 | |
| African | 1 | F | 0.235 [0.041; 1.337] | 0.103 | - | - | - | - | |
| CHD | 3 | F | 1.007 [0.750; 1.352] | 0.962 | 0.0% | 0.686 | 1.000 | - | |
| ACS | 2 | F | 1.013 [0.768; 1.336] | 0.925 | 0.0% | 0.668 | 1.000 | - | |
| CAD | 9 | F | 0.658 [0.487; 0.889] | 0.006 | 26.7% | 0.207 | 0.602 | 0.659 | |
| HB | 9 | F | 0.578 [0.390; 0.856] | 0.006 | 30.6% | 0.184 | 0.902 | 0.726 | |
| PB | 5 | F | 0.969 [0.806; 1.165] | 0.136 | 0.0% | 0.860 | 0.086 | 0.035 | |
| PCR-RFLP | 7 | F | 0.499 [0.302; 0.825] | 0.007 | 21.3% | 0.273 | 0.707 | 0.881 | |
| Taqman | 4 | F | 0.976 [0.798; 1.193] | 0.814 | 18.7% | 0.297 | 0.089 | 0.104 | |
| PCR | 3 | F | 0.855 [0.586; 1.246] | 0.414 | 0.0% | 0.700 | 0.296 | 0.028 | |
| Allelic (T vs. C) | Overall | 14 | R | 0.869 [0.761; 0.992] | 0.037 | 68.5% | 0.000 | 0.080 | 0.288 |
| Asian | 6 | R | 0.813 [0.630; 1.048] | 0.110 | 69.7% | 0.006 | 1.000 | 0.912 | |
| Caucasian | 7 | F | 0.978 [0.907; 1.055] | 0.571 | 44.2% | 0.096 | 0.174 | 0.484 | |
| African | 1 | F | 0.368 [0.200; 0.678] | 0.001 | - | - | - | - | |
| CHD | 3 | F | 1.000 [0.886; 1.128] | 0.999 | 0.0% | 0.953 | 1.000 | 0.871 | |
| ACS | 2 | F | 0.981 [0.874; 1.102] | 0.750 | 13.5% | 0.282 | 1.000 | - | |
| CAD | 9 | R | 0.785 [0.622; 0.992] | 0.043 | 76.3% | 0.000 | 0.348 | 0.620 | |
| HB | 9 | R | 0.772 [0.595; 1.001] | 0.051 | 75.3% | 0.000 | 0.466 | 0.830 | |
| PB | 5 | F | 0.984 [0.910; 1.064] | 0.682 | 0.0% | 0.909 | 0.462 | 0.471 | |
| PCR-RFLP | 7 | R | 0.765 [0.571; 1.026] | 0.074 | 73.0% | 0.001 | 0.548 | 0.434 | |
| Taqman | 4 | F | 0.981 [0.900; 1.070] | 0.669 | 58.0% | 0.066 | 0.308 | 0.231 | |
| PCR | 3 | F | 0.971 [0.845; 1.117] | 0.682 | 0.0% | 0.467 | 0.296 | 0.028 | |
Abbreviations: F, fixed-effects model; n, number of studies; R, random-effects model.