TABLE 3.

Summary of citations investigating the association between clinical characteristics and increased side‐effect expectations; different studies are separated by semi‐colons

	Unadjusted			Adjusted
	Association	Mixed association	No association	Association	Mixed association	No association
Decreased side‐effect severity (eg milder compared to more severe)	(34) study 1; (34) study 2; (43);(63);(87)		(28, 29) study 1; (29, 32) study 2; (42)			(40);(84, 85)
Increased side‐effect severity (eg more severe compared to milder)		(84, 85)
Increased likelihood or frequency of side‐effects	(2730) study 1; (29, 32) study 2; (42);(43);(77) risk design study;(78)		(50);(72) study 1; (72) study 2	(30) study 1; (40);(77) risk design study		(38)
Previous experience of symptoms from intervention	(54, 55);(64);(71)	(87)	(80)	(64)	(71);(83)
No previous experience of intervention			(48) study 1; (48) study 2		(73)
History of illness			(48) study 1; (48) study 2
Family history of illness						(73)
Lower effectiveness of medication	(49)	(77) benefit design study; (77) risk design study	(37)	(49)	(77) benefit design study; (77) risk design study	(38)
Existing physical symptoms	(48) study 2	(64)	(47);(48); study 1; (50);(89)	(51);(52)	(64);(73)	(49);(83)
Increased severity of existing physical symptom	(51)					(49)
History of nausea and vomiting in past experiences (eg pregnancy, motion sickness, anxiety).		(64)	(50)			(64)
Lower pre‐treatment quality of life/ worse general well‐being/ health status	(49);(51)			(39)	(84, 85)	(38)
Increased disease severity	(30) study 1		(37)	(30) study 1