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. 2020 Sep 3;11:1297. doi: 10.3389/fphar.2020.01297

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Copyright © 2020 Piesche, Roos, Kühn, Fettel, Hellmuth, Brat, Maucher, Awad, Matrone, Comerma Steffensen, Manolikakes, Heinicke, Zacharowski, Steinhilber and Maier

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Chemical structures + of different approved and (pre-) clinically developed therapeutic drugs containing Michael acceptors. The Michael acceptor moiety is highlighted in orange. Compounds marked with # are currently studied in clinical trials. CDDO, 2-cyano-3,12-dioxo-oleana-1,9(11)-dien-28-oic acid; DMF, dimethyl fumarate; MA, Michael acceptor; HMC, hesperidin methyl chalcone.