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. 2020 Sep 1;23(9):101517. doi: 10.1016/j.isci.2020.101517

Figure 3.

Figure 3

Condensate Formation of Fluorescent Structural Mutant p53 Variants and Their Dissolution by Aminothiazoles

(A) Saos2 cells expressing fluorescently tagged structural mutants show p53 condensates in the nuclei, which are dissolved after aminothiazole treatment. Stills (0 and 4:15 h) from time-lapse Videos 2A, 2B, and 2C. Scale bars, 10 μm.

(B) Kinetics of condensate dissolution in Saos2 cells expressing structural p53 mutants in response to treatment with aminothiazoles. Bars show mean with SD (n = 4). Exemplary data of multiple experiments are shown (n ≥ 2).