. 2020 Sep 1;23(9):101517. doi: 10.1016/j.isci.2020.101517

Table 1.

nDSF: Stabilization upon Compound Binding

Compound	nDSF p53^R175H D°C	nDSF p53^Y220C D°C	nDSF p53^WT D°C
BAY 249716	1.0	0.6	1.2
BAY 1892005	−0.4	1.1	0.8

nDSF, nano-differential scanning fluorimetry

Exemplary data of multiple experiments are shown (n ≥ 2). Ligands, that show a +ΔTm greater than six standard deviations from the mean of the control were considered as hit (stabilizer, bold).