Table 1.
Association between a decrease in PR3-ANCA and time to remission.
| Complete remission‡ | Sustained remission‡ | |||||
|---|---|---|---|---|---|---|
| HR | 95% C.I. | p | HR | 95% C.I. | p | |
| Overall (N*= 131) | ||||||
| Decrease by 2 months | ||||||
| Direct (n† = 93) | 1.51 | (0.95, 2.40) | 0.079 | 1.45 | (0.90, 2.42) | 0.139 |
| Capture(n† = 50) | 1.26 | (0.86, 1.84) | 0.245 | 1.14 | (0.75, 1.72) | 0.541 |
| ALBIA(n† = 120) | 2.11 | (0.86, 5.22) | 0.104 | 4.52 | (1.11, 18.42) | 0.035 |
| Decrease by 4 months | ||||||
| Direct (n† =101) | 1.75 | (1.03, 2.97) | 0.038 | 1.77 | (1.03, 3.28) | 0.050 |
| Capture (n† = 68) | 1.39 | (0.94, 2.05) | 0.102 | 1.29 | (0.86, 1.98) | 0.225 |
| ALBIA(n† = 121) | 1.73 | (0.70, 4.26) | 0.234 | 3.81 | (0.94, 15.53) | 0.062 |
| Negative by 4 months | ||||||
| Direct (n† = 74) | 1.07 | (0.73, 1.58) | 0.729 | 1.00 | (0.66, 1.51) | 0.996 |
| Capture (n† = 41) | 1.18 | (0.80, 1.75) | 0.413 | 0.97 | (0.62, 1.50) | 0.881 |
| ALBIA (n† = 55) | 1.08 | (0.73, 1.57) | 0.721 | 0.98 | (0.65, 1.49) | 0.939 |
*Total number of patients.
†
Number of patients who experienced the given decrease in ANCA by the stated time period.
‡
Separate analyses were performed for each remission definition and ANCA decrease definition using proportional hazards regression. Findings are summarized using the hazard ratio (HR) and corresponding 95% confidence interval. A hazard ratio significantly >1.0 indicates that experiencing the given ANCA decrease by the given time period is associated with a shorter time to achieving the given remission endpoint.