Table 3.
Association between a decrease in PR3 ANCA and time to remission—by Phenotype.
| Complete remission‡ | Sustained remission‡ | |||||
|---|---|---|---|---|---|---|
| HR | 95% C.I. | p | HR | 95% C.I. | p | |
| Renal Involvement (N*= 78) | ||||||
| Decrease by 2 months | ||||||
| Direct (n† =56) | 1.08 | (0.61, 1.91) | 0.801 | 1.20 | (0.65, 2.19) | 0.563 |
| Capture (n† = 30) | 1.09 | (0.67, 1.77) | 0.735 | 0.94 | (0.55, 1.59) | 0.809 |
| ALBIA (n† = 72) | 1.80 | (0.56, 5.78) | 0.323 | 2.08 | (0.51, 8.56) | 0.310 |
| Decrease by 4 months | ||||||
| Direct (n† = 62) | 1.40 | (0.70, 2.79) | 0.346 | 1.65 | (0.78, 3.50) | 0.191 |
| Capture (n† = 39) | 1.27 | (0.78, 2.08) | 0.341 | 1.00 | (0.60, 1.69) | 0.992 |
| ALBIA (n† = 73) | 1.12 | (0.35, 3.59) | 0.848 | 1.39 | (0.34, 5.70) | 0.647 |
| Negative by 4 months | ||||||
| Direct (n† = 41) | 1.03 | (0.63, 1.69) | 0.900 | 1.05 | (0.62, 1.77) | 0.849 |
| Capture (n† = 24) | 1.05 | (0.63, 1.75) | 0.846 | 0.83 | (0.47, 1.46) | 0.513 |
| ALBIA (n† = 29) | 1.11 | (0.68, 1.83) | 0.678 | 1.04 | (0.61, 1.79) | 0.878 |
| Capillaritis (N*= 105) | ||||||
| Decrease by 2 months | ||||||
| Direct (n† = 76) | 1.13 | (0.69, 1.85) | 0.631 | 1.15 | (0.67, 1.95) | 0.617 |
| Capture (n† = 41) | 1.06 | (0.69, 1.61) | 0.792 | 0.98 | (0.62, 1.55) | 0.922 |
| ALBIA (n† = 95) | 1.90 | (0.76, 4.71) | 0.169 | 3.96 | (0.97, 16.23) | 0.056 |
| Decrease by 4 months | ||||||
| Direct (n† = 83) | 1.39 | (0.78, 2.48) | 0.270 | 1.51 | (0.80, 2.87) | 0.208 |
| Capture (n† = 54) | 1.24 | (0.81, 1.90) | 0.330 | 1.13 | (0.71, 1.79) | 0.604 |
| ALBIA (n† = 96) | 1.49 | (0.60, 3.69) | 0.391 | 3.24 | (0.79, 13.26) | 0.102 |
| Negative by 4 months | ||||||
| Direct (n† = 59) | 1.01 | (0.66, 1.54) | 0.979 | 0.97 | (0.61, 1.54) | 0.896 |
| Capture (n† = 34) | 1.03 | (0.66, 1.58) | 0.911 | 0.84 | (0.51, 1.37) | 0.478 |
| ALBIA (n = 42) | 1.04 | (0.68, 1.59) | 0.862 | 0.99 | (0.62, 1.58) | 0.975 |
| DAH (N*= 38) | ||||||
| Decrease by 2 months | ||||||
| Direct (n† = 30) | 1.65 | (0.62, 4.35) | 0.313 | 1.34 | (0.46, 3.92) | 0.596 |
| Capture (n† = 12) | 0.81 | (0.38, 1.73) | 0.582 | 0.86 | (0.37, 2.01) | 0.727 |
| ALBIA (n† = 37) | 1.46 | (0.19, 10.98) | 0.713 | ∞ | (0.49, ∞) | 0.164 |
| Decrease by 4 months | ||||||
| Direct (n† = 33) | 3.02 | (0.70, 13.05) | 0.139 | 3.85 | (0.52, 28.69) | 0.189 |
| Capture (n† = 18) | 0.95 | (0.46, 1.94) | 0.885 | 0.97 | (0.43, 2.15) | 0.935 |
| ALBIA (n† = 37) | 1.46 | (0.19, 10.98) | 0.713 | ∞ | (0.49, ∞) | 0.164 |
| Negative by 4 months | ||||||
| Direct (n† = 21) | 1.33 | (0.63, 2.80) | 0.459 | 0.91 | (0.40, 2.05) | 0.820 |
| Capture (n† = 11) | 0.80 | (0.37, 1.75) | 0.574 | 0.48 | (0.18, 1.29) | 0.145 |
| ALBIA (n† = 17) | 1.27 | (0.62, 2.61) | 0.518 | 1.12 | (0.50, 2.51) | 0.778 |
| Granulomatous (N*= 102) | ||||||
| Decrease by 2 months | ||||||
| Direct (n† = 75) | 1.57 | (0.91, 2.70) | 0.108 | 1.44 | (0.81, 2.55) | 0.212 |
| Capture (n† = 42) | 1.41 | (0.91, 2.17) | 0.124 | 1.35 | (0.84, 2.15) | 0.213 |
| ALBIA (n† = 94) | 3.10 | (0.97, 9.95) | 0.057 | 3.22 | (0.79, 13.15) | 0.104 |
| Decrease by 4 months | ||||||
| Direct (n† = 79) | 1.95 | (1.06, 3.58) | 0.033 | 1.80 | (0.94, 3.43) | 0.076 |
| Capture (n† = 55) | 1.68 | (1.07, 2.64) | 0.026 | 1.57 | (0.97, 2.54) | 0.068 |
| ALBIA (n† = 95) | 2.41 | (0.75, 7.71) | 0.138 | 2.53 | (0.62, 10.32) | 0.197 |
| Negative by 4 months | ||||||
| Direct (n† = 63) | 0.97 | (0.62, 1.50) | 0.874 | 0.86 | (0.53, 1.37) | 0.518 |
| Capture (n† = 34) | 1.29 | (0.83, 2.00) | 0.260 | 1.10 | (0.68, 1.80) | 0.694 |
| ALBIA (n† = 47) | 1.02 | (0.66, 1.56) | 0.936 | 0.89 | (0.56, 1.42) | 0.629 |
*
Total number of patients with the given phenotype.
†
Number of patients with the given phenotype who experienced the given decrease in ANCA by the stated time period.
‡
Separate analyses were performed for each remission definition and ANCA decrease definition using proportional hazards regression. Findings are summarized using the hazard ratio (HR) and corresponding 95% confidence interval. A hazard ratio significantly >1.0 indicates that experiencing the given ANCA decrease by the given time period is associated with a shorter time to achieving the given remission endpoint.