FIGURE 1.

Illustrating the influence of the microenvironment on Treg cell metabolism, epigenome and function. The inflamed tissue microenvironment consists varying concentrations of dietary metabolites, oxygen as well as concomitant immunosuppressants. These entities can individually or collectively modulate various intracellular Treg cell pathways such as mammalian transporter of rapamycin (mTOR), mitochondrial/non-mitochondrial metabolism, nuclear receptors, the epigenome and genome. This modulation has downstream consequences for the Treg cell transcriptome and overall cell function.